Is the occurrence of degenerative complications of type 2 diabetes mellitus influenced by gender?

Takoua Moussa; Chaima Jemai; Sami Fitouri; Salem Dorsaf Ben; Ali Zohra Hadj; Olfa Lajili; Imen Hedfi; Yosra Htira; Mami Faika Ben

doi:10.1530/endoabs.99.EP1065

EP1065

Prev Next

Section Contents Cite

Endocrine Abstracts (2024) 99 EP1065 | DOI: 10.1530/endoabs.99.EP1065

ECE2024 Eposter Presentations Diabetes, Obesity, Metabolism and Nutrition (383 abstracts)

Is the occurrence of degenerative complications of type 2 diabetes mellitus influenced by gender?

Takoua Moussa ¹ , Chaima Jemai ¹ , Sami Fitouri ¹ , Dorsaf Ben Salem ¹ , Zohra Hadj Ali ¹ , Olfa Lajili ¹ , Imen Hedfi ¹ , Yosra Htira ¹ & Faika Ben Mami ¹

Err

Author affiliations

¹National Institute of Nutrition of Tunis, C

Introduction: Diabetes is a chronic disease that can lead to macroangiopathies and microangiopathies. The aim of our study was to describe the characteristics of these degenerative complications according to gender.

Methods: We conducted a cross-sectional study from September to December 2023, at Department C of the national institute of nutrition of Tunis. We included 70 patients with type 2 diabetes, evolving from 5 to 20 years, and with ages ranging from 35 to 65 years. Sex ratio was 1. The two groups of men and women were matched for age, diabetes duration, BMI and Hba1c. Clinical and biological data were collected from medical records. Data were analyzed using SPSS 23.

Results: The mean ages of the men and women were 56.23±6.77 and 57.17 ±8.2 years respectively (P=0.65). 17 men and one woman were active smokers (P=0.021). The mean body mass index (BMI) for women and men was 30.26±6.4 and 26.24±5.68 kg/m² respectively (P=0,06). Mean HbA1C was 9.2±1.1% with extremes of 8.5 and 12% (8.7±1.3% and 9.2±1.1% for men and women respectively, P=0,23). The association between gender and microvascular and macrovascular complications did not reach statistical significance with P=0.569 and 0.06 respectively. We found a statistically significant association between male gender and the occurrence of obliterating arteriopathy of the lower limbs (P=0.042). No statistically significant association was found with either gender for retinopathy (P=0.4), nephropathy (P=0.33), autonomic neuropathy (P=0.16), peripheral neuropathy (P=1), coronary artery disease (P=1) nor stroke (P=0.63).

Conclusion: According to our study, chronic obliterating arteriopathy of the lower limbs seems to affect men more frequently. Tobacco could be a factor biasing this result.