ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)
The usefulness of 18F-choline PET/CT in patients with negative findings on 99mTc-sestamibi SPECT/CT in Locating Hyperfunctioning Parathyroid Glands in Primary Hyperparathyroidism
Ante Mandic 1 , Ivana Kraljevic 2,3 , Tanja Skoric Polovina 2 , Karin Zibar Tomsic 2 , Tina Dusek 2,3 , Annemarie Balasko 2 , Mirsala Solak 2 & Darko Kastelan 2,3
1University Clinical Hospital Mostar, Department of Endocrinology, Mostar, Bosnia and Herzegovina; 2University Hospital Centre Zagreb, Zagreb, Croatia; 3School of Medicine, University of Zagreb, Zagreb, Croatia
Objective: This study aimed to investigate the diagnostic performance of 18F-choline PET/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT/CT in locating hyperfunctioning parathyroid tissue in primary hyperparathyroidism patients.
Methods: We conducted a retrospective study involving patients who were operated on due to primary hyperparathyroidism from April 2019 to March 2022. The analysis focused on patients undergoing 18F-choline PET/CT scan due to previously negative or inconclusive findings on 99mTc-sestamibi SPECT/CT in order to localize a hyperfunctioning parathyroid gland(s). Pathohistological reports were used as a reference standard for the assessment of imaging results.
Results: The study included 29 patients (23 (79.3%) females), with a mean age of 56.3 years (range 25–74). Pathohistological analysis revealed 36 glands. The detection rate of 18F-choline PET/CT in per lesion analysis was 88.9% (95% CI 70.8–97.7).
Conclusion: The results of our study showed the significant usefulness of 18F-choline PET/CT in patients with negative or inconclusive results of 99mTc-sestamibi SPECT/CT in accurately locating hyperfunctioning parathyroid glands in primary hyperparathyroidism patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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