ECE2024 Eposter Presentations Adrenal and Cardiovascular Endocrinology (155 abstracts)
Adrenal lesions do matter in the course of primary aldosteronism: a comparative analysis of Conn’s adenoma vs bilateral adrenal hyperplasia
Siddiqa Soomauroo 1 , Faten Hadjkacem 1 , Ahmad Ridwaan Auckburally 2 , Abdelmuhaymen Missaoui 1 , Souhir Maalej 1 , Wiem Feki 2 , Zeinab Mnif 2 , Mouna Mnif 1 , Mohamed Abid 1 & Nabila Rekik 1
1Hedi Chaker University Hospital, Department of Endocrinology, Sfax, Tunisia; 2Hedi Chaker University Hospital, Department of Radiology, Sfax, Tunisia
Introduction: Primary aldosteronism (PA) is commonly identified as the main cause of secondary hypertension. It is becoming increasingly wide-spread, affecting between 1 and 30% of people suffering from hypertension. We aim to determine the different characteristics between aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH).
Patients and methods: Retrospective descriptive and analytical study concerning 40 patients with PA, collected inthe endocrinology department of the Hedi Chaker University Hospital of Sfax, over the period of 10 years from January 2010 to December 2022. In an endeavour to determine the distinct characteristics of the 2 main aetiologies, we defined 2 groups: the first group APA (n=17) and the second group BAH (n=20).
Findings: The mean age of our patients was 55.4 years old. The aetiology of PA was dominated by BAH in 20 cases. The sex ratio (M/F) in the group APA was 0.55 whereas in the group BAH, the sex ratio was 1. Statistical analysis between these two groups revealed no significant differences in epidemiological and clinical data, with the exception of asthenia, which was more prominent in the BAH group, with a significant difference (75% vs. 41.2%; P=0.037), and fasting blood glucose was significantly higher in the BAH group than in the APA group (P=0.018). In terms of hormonal profile, serum aldosterone and renin levels, as well as aldosterone to renin ratio (ARR) were higher in the APA group, but the difference did not reach statistical significance for these parameters. We found no significant difference in the incidence of metabolic syndrome between the 2 groups (APA=82.4% vs BAH=80%).
Conclusion: APA is generally observed in individuals between the third and fifth decade of life. The symptoms associated with this entity are generally more severe, with higher blood pressure levels and more pronounced hypokalemia compared with other forms of PA.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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