Endocrine Abstracts

Introduction: The Gut-Brain Axis (GBA) is implicated in various conditions, including migraine, headache disorders, Irritable Bowel Syndrome (IBS), hypertension, and vascular dysregulation. While ophthalmic artery Doppler shows promise in conditions like migraine and stroke prevention [2], effective treatments targeting these mechanisms are still under exploration. Probiotic therapy, as a potential molecular and cellular modulator, may balance regulatory systems leading to pathological conditions.

Aim: To explore the relevance of ophthalmic artery Doppler as a test for the efficacy of probiotic therapy in potentially modulating the gut-brain axis.

Methods: A cohort of 10 patients diagnosed with migraine, headache disorders, seasonal dizziness, nausea, IBS, and hypertension underwent general clinical, lab tests, and radiology tests for a metabolic biomarker panel. Probiotic strains, including Lactobacillus and Bifidobacterium genera, were administered at a dose of 10^9 CFU per day for ten days was based on symptoms [3-5]. Ophthalmic artery Doppler analysis was conducted before and after interventions to assess changes in blood flow parameters. Standardized scales evaluated improvements in eye symptoms. Kidney Doppler, blood flow resistive index in segmental arteries, and parameters like visceral fat were also tested.

Results: Analysis revealed significant changes in ophthalmic artery Doppler parameters post-interventions. Peak systolic velocity increased from 25 cm/sec to 35 cm/sec (P<0.05), indicating enhanced blood flow, accompanied by a decrease in resistivity index from 0.78 to 0.65 (P<0.01), suggesting reduced vascular resistance. Similar trends were noted in ciliary and other ophthalmic parameters. Effective outcomes were observed in kidney blood flow, with decreased IR. Low and normal BMI patients experiencing treatment effects exhibited increased visceral fat. Other symptoms related to GBA, including IBS, asthma, and hypertension, showed alleviation.

Conclusion: Microbiome modification via probiotic therapy may impact certain diseases in both short-term and long-term scales. The Gut-Brain Axis emerges as a potential mechanism, urging further exploration and clinical consideration. Future research should delve into mycobiome, neuromodulators, interleukins (IL-6), cortisol levels, metabolites, Short-Chain Fatty Acids (SCFA), serotonergic agents, CGRP-signaling, hypoxic signaling, and the modulation of calcitonin gene-related peptide (CGRP) within the trigeminal system [1-3].

References : 1. Bubnov R. Effects of us-guided trigger point interventions on ophthalmic artery doppler parameters and their predictive value for stroke prevention in patients with migraine and headache disorders. International Journal of Stroke. 2023;18(3_suppl):439. https://doi.org/10.1177/17474930231201072#sec-462. Bubnov R, Spivak M. Individualized Short-term Probiotic Therapy of Metabolic Syndrome According to the Host’s Phenotype. Journal of Clinical Gastroenterology. 2020; 54:25–26.