Endocrine Abstracts

Background: UCSF Cancer Center is committed to offering all patients information on Advance Directives; however, many patients do not have their wishes well-documented in their EMR. Our clinic has implemented a workflow for introducing advance care planning discussion into treatment teaching sessions. We have begun to share this workflow throughout the cancer center. Many patients in our clinic have metastatic disease and are treated for months to years by our team. It is impo...

Background: 10% of pancreatic neuroendocrine tumors (pNETs) are thought to be related to inherited syndromes, (MEN1, MEN4, VHL, NF1 and TSC). Growing evidence suggests, that clinically sporadic appearing pNETs can harbor germline mutations. Here, we report the prevalence of pathological/likely pathological germline variants (P/LP) in 2 cohorts: 1) High-risk and 2) Unselected.Methods: We retrospectively collected clinical data of pNET patients seen at MD ...

Background: Gastroenteropancreatic mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare entity consisting of two morphologically distinct populations of cells, one of which is neuroendocrine and one which is non-neuroendocrine. MiNENs typically contain high grade neuroendocrine carcinoma, conferring a poor prognosis. Due to the rarity of this diagnosis, data is limited and therefore, we sought to add to the current clinical understanding of this diagnosis.<p ...

Background: Pancreatic neuroendocrine tumors (panNETs) are heterogeneous, with grade (G) defined by Ki67 proliferation index (<3% G1, 3-20% G2, and >20% G3) or mitotic rate. Previous studies suggest that baseline Ki67 index may be confounded by biopsy site (primary or metastasis), biopsy technique and primary tumor size. Ki67 differences leading to grade discordance in PanNETs at baseline is relatively understudied. Our study aims to evaluate grade discordance in synch...

Background: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have highly heterogeneous growth rates, yielding broad ranges of radiographic imaging intervals in standard guidelines, creating uncertainty for clinicians and patients. Chromogranin A (CgA) is released by GEP-NET cells and has been associated with increased tumor burden. However, clinical utility of CgA measurement has been limited by the lack of prospective validation studies and by different sensitivity for...

Background: Patients with neuroendocrine tumours (NETs) and acromegaly are commonly treated with somatostatin analogs (SSAs), such as octreotide and lanreotide depot formulations. The Pharmathen syringe is now available in several European countries and the USA for lanreotide depot injection. When using SSAs, confidence in and ease of use with syringes are important for decision-making in long-term therapy. The aim of the PRESTO 3 study was to compare nurses’ preference f...

Background: The incidence of young-onset colorectal adenocarcinoma is predicted to continue rising over the next decade. Overall, data about young onset neuroendocrine tumors (NET) is scarce. In this analysis, we sought to investigate trends and differences in survival for colorectal NET in the young-onset population and to compare this with the average onset population. In addition, we seek to compare differences between adenocarcinoma and NET in the young-onset population. <...

Background: Preoperative grading of pancreatic neuroendocrine tumors (PNET) incorporating Ki-67 index can identify PNETs at low risk of progression and prevent unnecessary surgical resection. The aim of this study was to perform a comprehensive literature search and meta-analysis to compare the accuracy of Ki-67 based grading of PNETs between endoscopic ultrasound (EUS) guided fine needle aspiration (FNA) vs fine needle biopsy (FNB).Methods: Literature s...

Background: Lu177 has shown efficacy in advanced NET with significant hematologic toxicity, including therapy-related myeloid neoplasm (t-MN). CH is defined by acquisition of somatic mutations in hematopoietic stem cells with potential for expansion over time. In this study, we aimed to assess the prevalence of CH in NET patients (pts) prior to Lu177 along with the incidence of cytopenia in NET pts treated with lu177 based on the CH status at baselineMet...

Background: Improved management for patients with cyanotic congenital heart disease (CCHD) has led to prolonged lifespan and an increase in patients with CCHD presenting with pheochromocytoma and paraganglioma (PPGL) has been noted. PPGL susceptibility genes including VHL, SDH(x), FH, EPAS1 have been connected to a common signaling pathway that activates hypoxia-inducible factors. 4 of 5 patients with CCHD and PPGL were previously noted to have a somatic gain-of-function mutat...

Background: Paragangliomas of head and neck (HNPPGLs) are rare and mostly slow growing tumors arising from neural crest-derived cell clusters and have high rate of genetic mutation, up to 40% germline mutations and 30% somatic mutations.Methods: Retrospective review of institutional experience with clinical evaluation and management of HNPPGLs.Results: Among 174 patients with HNPPGLs diagnosed from 1981 to 2023, 116 (67%) were wome...

Background: The diagnosis of neuroendocrine carcinoma of the cervix is rare, they are less than 2% of cervical cancers, and it is considered an unusual entity of diagnosis. In Peru there is only one published case record of this histological type of neoplasm. Methods: Data was taken from a patient from the electronic medical record of the Alberto Sabogal Sologuren National Hospital in Lima - Peru, who received treatment with etoposide and cisplatin (EP),...