Endocrine Abstracts

Background: In March 2022, NICE guidelines advised that real-time continuous glucose monitoring (rtCGM) be offered to all children and young people with type 1 diabetes mellitus (T1DM). Using rtCGM alongside the hybrid closed loop system (HCLS), has transformed management of T1DM in adults and children alike by linking insulin delivery to sensor glucose levels.

Aim: To evaluate how the T-Slim pump with control IQ HCLS affects both clinical parameters and quality of life in children/their parent(s) within a group of 11 paediatric patients with T1DM aged 8–16 in Gloucestershire.

Methods: Clinical parameter data was collected retrospectively from rtCGM system (Dexcom G6). Clinical parameters assessed were time in range, % time spent in hypoglycaemia, % time spent in hyperglycaemia, HbA1c and mean glucose. Quality of life data was collected using a quality of life scoring sheet. Scores were calculated using parent interview answers. Areas measured included problems with symptoms, problems with treatment, worries, communication regarding illness with family/friends/healthcare professionals and parental opinions. For both clinical parameters and quality of life, data was collected before, at 6 months and at 1 year.

Results: Participants ranged from 8 to 16 years, 45.5% female. Patients were under the Gloucestershire Royal Hospital paediatric diabetes team and had had a diagnosis of T1DM for between 3.1 and 13.8 years. At study end point, there was an overall improvement in all clinical parameters – 4.6% absolute % increase in median TIR, 2.13% absolute % decrease in median mean glucose, 1.6% absolute % decrease in median time spent in hypoglycaemia, 9.6% absolute % decrease in median % time in hyperglycaemia, 6.15% absolute % decrease in HbA1c. There was also a 24.5% improvement in quality of life. However, mean glucose and time in range values were better at 6 months than at 1 year.

Conclusion: The T-slim pump with control IQ HCLS was associated with improvement in both clinical parameters and quality of life, in our patients with T1DM.