BSPED2023 Poster Presentations Obesity 2 (8 abstracts)
The prevalence of monogenic obesity in Turkish children with non-syndromic early onset obesity. A multicenter study
Ayşehan Akıncı 1 , Doğa Türkkahraman 2 , İbrahim Tekedereli 1 , Leyla Özer 3 , Bahri Evren, 1 , Ibrahim Sahin 1 , Tarkan Kalkan 4 , Yusuf Cürek 4 , Emine Camtosun 1 , Esra Doger 5 , Aysun Bideci 5 , Ayla Güven 6 , Erdal Eren 7 , Ozlem Sangün 8 , Atilla Cayır 9 , Pelin Bilir 10 , Ayça Törel Ergür 11 & Oya Ercan 12
1İnönü University Faculty of Medicine, Department of Pediatric Endocrinology and Diabetes, Malatya, Turkey; 2Antalya Training and Research Hospital, Antalya, Turkey; 3Yüksek İhtisas University Faculty of Medicine, Department of Molecular Genetics, Ankara, Turkey; 4Antalya training and research hospital, Antalya, Turkey; 5Gazi University Medical Faculty, Ankara, Turkey; 6Baskent University Pediatric Endocrinology, İstanbul, Turkey; 7Uludağ University Pediatric Endocrinology, Bursa, Turkey; 8Baskent University Pediatric Endocrinology, Adana, Turkey; 9Erzurum Training and Research Hospital, Erzurum, Turkey; 10Ankara University Pediatric Endocrinology, Ankara, Turkey; 11Ufuk University Pediatric Endocrinology, Ankara, Turkey; 12Istanbul Cerrahpaşa University, Istanbul, Turkey
Background: Objective: Non syndromic monogenic obesity is a rare cause of early onset severe obesity in the childhood period. This form may not be distinguishable from other forms of severe obesity without genetic analysis, particularly if patients do not exibit any physical abnormalities or developmental delay. The aim of this study was to screen 41 different obesity-related genes in children with nonsyndromic early onset severe obesity.
Patients and methods: Children with severe (body mass index-standard deviation score >3) and early onset (<7 years) obesity were screened by next-generation sequencing based, targeted DNA custom panel for 41 known-obesity-related genes and the results were confirmed by Sanger technique.
Results: Six novel variants were identified in five candidate genes in seven out of 105 children with severe obesity; two in SIM1 (p.W306C and p.Q36X), one in POMC (p.Y160H), one in PCSK1 (p.W130G fs Ter8), two in MC4R (p.D126E) and one in LEPR (p.Q4H). Additionally, two previously known variations in MC4R were identified in four patients (p.R165W in three, and p.V166I in one).
Conclusion: We identified six novel and four previously described variants in six obesity-related genes in 11 out of 105 childrens with early onset severe obesity. The prevalence of monogenic obesity was 10.4% in our cohort.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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