Endocrine Abstracts

Introduction: The diagnosis of central hypothyroidism can be challenging and confused with other causes of low thyroxine concentrations without TSH elevation. The response of the thyroid hormone axis before and after treatment is reported in children with Central Hypothyroidism [CH] as part of an exercise aimed at validating free thyroxine reference ranges.Methods: Roche Elecsys Cobas TSH and FT4 immunoassays were used. ...

28-year-old pregnant female had been followed with serial scan and thyroid function tests with concern of foetal goitre. She had a previous stillbirth at term where a goitre was found at post-mortem and cause of death was hypothesized to be high output cardiac failure secondary to thyrotoxicosis. Mother’s thyroid function and thyroid antibodies were negative throughout pregnancy. Baby girl was born at 33 weeks by Caesarean Section with a birth weight of 1.785 kg She had a...

Case summary: 7 yr old girl referred by GP to the cardiology clinic with heart murmur. Mother reported to GP about facial and periorbital puffiness intermittently for the last 2 years. Cardiology clinic review showed 1/6 short systolic murmur with small pericardial effusion. Pericardial effusion was initially thought to be possible post viral illness and the facial puffiness which remained unexplainable. A repeat Echo at 3 months later showed persistence of pe...

Aim: The purpose of this review is to outline the key elements that should be taken into account when making a determination regarding the prescription of L-Thyroxine for a pediatric patient diagnosed with subclinical hypothyroidism (SH).Methods: A systematic review of the literature was conducted to evaluate the current evidence regarding the management of subclinical hypothyroidism in children.<p cla...