SFEBES2023 Poster Presentations Neuroendocrinology and Pituitary (74 abstracts)
Pituitary apoplexy: a retrospective study of 71 cases from a single center
Sandra Ghenoiu 1 , Andreea Sandu 1 , Anda Dumitrascu 1 , Daniela Alexandrescu 1 , Cristina Capatina 2,1 & Catalina Poiana 1,2
1CI Parhon National Institute of Endocrinology, Bucharest, Romania. 2Carol Davila UMPh, Bucharest, Romania
Background and objective: The purpose of this study was to retrospectively analyse the clinical, imaging and hormonal features, as well as the therapeutic outcomes in a series of consecutive patients presenting with pituitary apoplexy (PA).
Design: We retrospectively reviewed 71 case-records of patients with PA admitted during 2019 in a single tertiary endocrinology center.
Results: 71 patients (40 men, 31women) were included, 56.3% of them presenting typical symptoms of PA (subgroup 1), 43.7% with a-/oligosymptomatic tumor haemorrhage on imaging (subgroup 2). The most common presenting symptoms in subgroups 1 and 2 were headache (85% vs 9.7 %), visual abnormalities (77.5% vs 45.2%) and digestive symptoms (30% vs 3.2%, respectively). At diagnosis, hormonal deficiency was observed in 27 (38%) patients. Neurosurgical intervention was recommended (after evaluation by multidisciplinary team) in 41 patients (58%), 24 of them with classical PA. 75.6% of operated cases and 88.8% of cases managed conservatively presented tumor remnant. Vision improvement was obtained in 64.5% of the operated and 82% of conservatively managed cases. 61% of all cases required chronic hormonal replacement therapy (more frequently in the surgical group).
Conclusion: Complex management of PA frequently leads to visual improvement but longstanding hypopituitarism.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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