SFEBES2023 Poster Presentations Metabolism, Obesity and Diabetes (70 abstracts)
EarLy Surveillance for Autoimmune type 1 diabetes (ELSA) – paediatric, general population screening in the UK
Lauren Marie Quinn 1 , Renuka Dias 2 , Rajeeb Rashid 3 , Joanna Garstang 4 , David Shukla 5 , Sheila Margaret Greenfield 6 , Alex Richter 7 , Parth Narendran 8 & Brandon Shu Huang Low 9
1Institute of immunology and Immunotherapy, University of Birmingham, Birmingham, United Kingdom. 2Department of Diabetes, Birmingham Children’s Hospital, UK; INNODIA Principle Investigator, Birmingham Children’s Hospital,, Birmingham, United Kingdom. 3School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, Glasgow, United Kingdom. 4Birmingham Community Healthcare Trust, Birmingham,, Birmingham, United Kingdom. 5Clinical Research Lead for Primary Care (West Midlands), National Institute for Health and Care Research; Clinical Research Fellow, Institute of Applied Health Research, University of Birmingham, Birmingham, Birmingham, United Kingdom. 6Institute of Applied Heath Research, University of Birmingham, Birmingham, United Kingdom. 7Head of Clinical Immunology Service, University of Birmingham, Birmingham, United Kingdom. 8Department of Diabetes, University Hospitals of Birmingham, Birmingham, United Kingdom. 9University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom
Background: Children with pre-symptomatic type 1 diabetes (T1D) can be identified through testing for circulating islet autoantibodies (AAb). Identifying children at risk reduces diabetic ketoacidosis at onset and allows participation in trials aiming for immunoprevention. The EarLy Surveillance for Autoimmune diabetes (ELSA) study is exploring feasibility and acceptability of UK paediatric general population screening.
Methods: The ELSA study runs from July 2022 to August 2024 and aims to recruit 20,000 children aged 3-13 years. ELSA is screening for AAb via dried blood spot (DBS) and subsequent staging via oral glucose tolerance testing. ELSA is exploring feasibility and acceptability of UK paediatric general population screening.
Results: In total, 6104 children are consented, including 5968 for home testing and 136 for community settings (school, general practice). Families are principally White European (89%) and 54% have a family history of T1D. Thus far, 3421 kits are returned with 3324 children screening negative and 86 screening positive for AAb. Only 2 DBS kits failed due to insufficient sample. On confirmatory AAb testing, 5 are false positive (8%), 18 are single (28%) and 41 (64%) are multiple AAb positive. Of the multiple AAb children, 27 are stage 1, 2 are stage 1 and 1 child is stage 3. All families agreed to confirmatory testing, staging and education and all expressed interest in INNODIA for monitoring.
Conclusion: Social media is an effective route to recruitment. Community outreach to schools and general practices is underway. Exploring acceptability and barriers to screening are key outcomes for this study.
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Endocrine Abstracts
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