SFEBES2023 Poster Presentations Endocrine Cancer and Late Effects (15 abstracts)
Survival rates in metastatic gastroenteropancreatic neoplasms after multidisciplinary approach
Raluca Trifanescu 1,2 , Madalina Iftimie 2 , Alexandra Mohora 2 , Iustin Toma 1,2 , Oana Trifanescu 1,3 & Catalina Poiana 1,2
1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. 2"C.I. Parhon" National Institute of Endocrinology, Bucharest, Romania. 3"Al. Trestioreanu" Institute of Oncology, Bucharest, Romania
Background: Prevalence of neuroendocrine neoplasms is increasing and multidisciplinary approach is mandatory. This study aimed to assess the outcome of patients with gastroenteropancreatic neoplasms (GEP NEN) presenting in a tertiary endocrine center.
Methods: Retrospective study on 36 patients (16 M/20 F) with pathology confirmed GEP NEN, aged 51.9 ± 12.7 years. Serum chromogranin A, serotonin, neuron-specific enolase, NT proBNP, urinary 24h 5 hydroxyindoleacetic acid were measured. Imaging with computed tomography, magnetic resonance were used for staging and assessment of tumour size. Whole-body somatostatin receptor (SSTR) imaging was performed in a subgroup.
Results: Metastatic disease was present in 21 patients (58.3%). Median progression free survival (PFS) was 36 months, with no significant differences between different localizations. Median PFS was not reached for G1 tumors, was 26 months for G2 tumors and 3 months for G3 tumors. Median overall survival was not reached, with 86% of patients’ alieved at 3 years, and 80% of patients’ alieved at 5 years. Tumor size and serotonin levels at diagnosis were significantly higher in patients that will progress later than in patients with no further progression, P= 0.05 and 0.01 respectively.
Conclusions: initial endocrine assessment is helpful in stratifying risk in gastroenteropancreatic tumors and early diagnosis with smaller tumors improved prognosis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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