Endocrine Abstracts

Background: Study the frequency of thyroid, adrenal, and gonadal dysfunction in HIV-infected patients and correlate them with CD4 cell count levels. Design: Cross-sectional study of 760 HIV-infected adults. in the period from January 2016 to December 2018.

Methodology: Free T3, free T4, TSH, Cortisol, FSH, LH, testosterone and estradiol were estimated by the radioimmunoassay method. Hormone levels and their correlation with CD4 count were compared. Qualitative variables were evaluated using the Chi-square test or Fisher’s exact test, and in the case of numerical or quantitative variables, the Student’s T or Mann-Whitney test was used.

Results: Of the total sample, only 43 presented endocrine disorders. The prevalence of gonadal dysfunction (88.3%) was the most frequent endocrine dysfunction, followed by thyroid (60.4%) and adrenal (27.9%) dysfunction. Secondary hypogonadism (68.4%) was more frequent than primary (31.6%). The difference in hormonal dysfunction between genders was not statistically significant (P > 0.05). 27.9% of the patients presented multiple alterations. There was negligible or no correlation between CD4 count and serum hormone level.

Conclusion: In our study, endocrine dysfunction was quite common among HIV-infected patients, + there was no correlation between these alterations and CD4 count. Longitudinal studies should be carried out with a larger population to correlate the association of endocrinopathy and HIV as well as its responsible mechanisms and the risks in this population.