SFEBES2023 Poster Presentations Metabolism, Obesity and Diabetes (70 abstracts)
The effects of bariatric surgery on blood pressure management in Type 2 Diabetes: Insights from a ten-year follow up study
Fahmida Mannan 1,2 , Ryan Wiltshire 1 , Parisa Ghaffari 1 , Unaiza Waheed 1 , Akheel Syed 1 , Dragan Zdravkovic 1 , Rachelle Donn 3 , Handrean Soran 3 & Adrian Heald 1,3
1Department of Endocrinology and Diabetes, Salford Royal NHS Foundation Trust, Manchester, United Kingdom. 2Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, Manchester University, Manchester, United Kingdom. 3The School of Medicine and Manchester Academic Health Sciences Centre, Manchester University, Manchester, United Kingdom
Background: The prevalence of obesity associated comorbidities, such as Type 2 Diabetes(T2D) and hypertension, continues to rise globally. Our study aimed to describe the long-term effects on blood pressure management in individuals with T2D post bariatric surgery in a single centre prospective observational cohort study in North-West England.
Methods: We undertook a 10-year prospective cohort study on people who underwent bariatric surgery (gastric bypass/sleeve gastrectomy) between 2009 - 2012 at a single tertiary surgical centre in North-West England, UK. Baseline preoperative/follow-up postoperative data were obtained from electronic patient records including blood pressure (BP) readings and initiation of pharmacological treatment. Parameters include BP readings, HbA1c, BMI and antihypertensive medication use was obtained from electronic patient records at regular intervals up to 10 years, to ascertain longitudinal outcomes in BP, BMI and HbA1c.
Results: 119 individuals were included in the study. Optimal metabolic health state was achieved at 12 months post-surgery for BMI (-14.8kg/m2 (95%CI: 10.4-16.2, P<0.001)), systolic BP (sBP) (-15.0mmHg 95%CI: 8.2-21.8mmHg, P<0.001)), diastolic BP (dBP) (-8.1mmHg, 95%CI: 4.3-11.9, P<0.001)) and HbA1c (-24.4mmol/mol, 95%CI: 18.3-30.6, P<0.001). A sustained reduction in both sBP/dBP was maintained for up to 5years, mirroring a reduction in concurrent use of antihypertensive medications (164 prescriptions v 66 at 5years). At latest follow-up, there was an observed increase in antihypertensive prescription (95 v 66) yet there was no statistically significant change in mean BP. Furthermore, the number of individuals with clinically diagnosed hypertension (BP 140/90 or more was lowest at 5years (n=53 v 86 pre-op) before rising at the latest follow-up (n=64) in hand as did BMI(+3.1kg/m2) and HbA1c(+7.5mmol/mol).
Conclusion: Our study demonstrates that bariatric surgery has a sustained positive impact on BP management as reflected by both absolute measurements/reduction in antihypertensive medication use, with slight reduction in benefit beyond 5year follow-up.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more