Endocrine Abstracts

Adipocytes are important metabolic buffers and endocrine regulators of energy expenditure and satiety. Adipocyte dysfunction, either genetic or as observed in acquired obesity, is linked to hallmarks of the metabolic syndrome. I will discuss novel translational regulators of adipocyte function and focus on the role of the proteasome for cellular protein quality control, ER stress, and maintenance of healthy brown and white adipocytes in obesity, diabetes, and atherosclerosis i...

Many metabolic diseases, including type 2 diabetes, strongly associate with obesity, making obesity one of the major health challenges facing the world today. Obesity is usually accompanied by an increase in fat cell size. As fat cells enlarge, they begin to secrete factors which promote adipose tissue inflammation and dysfunction. We recently describe a mechanism connecting an increase in fat cell size (hypertrophy) with the secretion of pro-inflammatory factors: We show that...

The prevalence of both type 2 diabetes and depression are increasing globally and previous research has demonstrated evidence that diagnosis with both conditions leads to poorer diabetes control and an increased likelihood of developing treatment resistant depression. However, the relationship between type 2 diabetes and depression is complex with many unanswered questions. The aim of our research is to use longitudinal health records and genetic analyses in 10,000s of individ...