ea0094s1.1 | Bones from Bench to Bedside | SFEBES2023
Bonewald Lynda
Osteocytes make up over 90-95% of bone cells in the adult skeleton making their total cellular mass greater than the mass of the brain. These cells can exist for decades in the bone matrix, much longer than osteoblasts or osteoclasts. In addition to being mechanosensory cells, osteocytes are also secretory cells, releasing sclerostin that inhibits osteoblastic bone formation and producing Rankl, the major activator of osteoclasts. Mechanical loading reduces both sclerostin and...