Endocrine Abstracts

Leydig cell tumors are a rare form of hormonally active testicular tumors. They often present as a painless testicular mass. Infertility as the primary presentation is rare in this condition. A 32 year old man, presented with symptoms of infertility and hypogonadism which had occurred over a period of 1 year. He however was found to have a raised testosterone and estradiol levels as well as suppressed gonadotrophin levels. The patient had a historic sperm analysis done 2 years prior which was normal and a second one done 2 months prior to his presentation to us which showed azoospermia. An ultrasound of his testes revealed a 2.9x 1.6cm testicular mass. He underwent a left radical orchidectomy which revealed the mass to be a Leydig Cell tumour. 6 months after his surgery, his testosterone and estradiol levels normalized and a repeat sperm analysis showed a normal sperm count and morphology. We this case we wish to highlight an unusual presentation of Leydig cell tumor in which the primary presenting symptoms was that of infertility with azoospermia and hypogonadal symptoms but with contrasting hyperandrogenism.