Endocrine Abstracts

Introduction: Type 2 diabetes is an important comorbidity during the course of COVID-19. However, the impact of blood glucose control on the degree of medical interventions required and on mortality in patients with COVID-19 remains uncertain.

Methods: Single-center retrospective study of 306 cases of COVID-19, of which 43 had pre-existing type 2 diabetes for 6 months. Qualitative variables were assessed using the Chi-square test or Fisher’s exact test, and in the case of numerical or quantitative variables Student’s T or Mann-Whitney tests were used. We found that subjects with type diabetes required more medical interventions and had significantly higher mortality (9.6% vs. 3.4%; adjusted hazard ratio, (1.8)) and multi-organ injury than non-diabetic individuals.

Results: Discovered We found that subjects with type 2 diabetes required more medical interventions and had significantly higher mortality (9.6% vs. 3.4%; adjusted hazard ratio, (1.8)) and multi-organ injury than non-diabetics. Furthermore, we found that well-controlled glucose (glycemic variability within 3.9 to 10.0 mmol/l) was associated with markedly lower mortality compared with those with poorly controlled glycemia (upper limit of variance). glycemic stability greater than 10.0 mmol/l) (adjusted HR, 0. 14) during hospitalization.

Conclusion: These findings provide clinical evidence correlating optimized glycemic control with better outcomes in patients with COVID-19 and pre-existing diabetes.

Keywords: Mortality, Endocrinology, Diabetes.