Endocrine Abstracts

Background: 11C-methionine positron emission tomography (Met-PET) is a potentially important imaging adjunct in the diagnostic workup of pituitary adenomas, including somatotroph tumours. Met-PET can identify residual or occult disease and make definitive therapies accessible for a subgroup of patients who would otherwise require lifelong medical therapy. However, data on its use is still limited to small case series. Here, we report the currently largest sing...

Background: Refractory hypothyroidism poses a clinical dilemma, with great difficulty to treat. Novel cases have targeted intramuscular (IM) levothyroxine (LT4) as a potential treatment for cases resistant to oral LT4. We discuss a patient who became intolerant of IM LT4 after 18 years of treatment, thus SC LT4 was initiated as alternative management.Case Presentation: 35-year-old female with diagnosed Schmidt’s Syn...

Introduction: Adrenal vein sampling (AVS) is considered gold-standard for diagnosis of unilateral primary aldosteronism (PA), and necessary pre-surgery. Imaging-AVS discordance may occur in up to 30-40% of PA-AVS series, and presents a diagnostic dilemma which may preclude surgery. Lateralization by AVS is defined as the ratio of aldosterone concentrations normalized by cortisol from each adrenal vein, and is thus sensitive to any pathologic asymmetry in corti...

National training surveys demonstrate that medical trainees feel under-prepared for practice and under-prepared for managing emergencies, such as diabetic ketoacidosis (DKA). It is challenging for traditional clinical training to guarantee first-hand exposure to all medical emergencies as they occur at random and often out-of-hours, resulting in only minority of students witnessing many emergencies first-hand. It is unfeasible for most universities to provide in-person simulat...