EYES2023 ESE Young Endocrinologists and Scientists (EYES) 2023 Oral communication 7: Diabetes, Obesity and Metabolism (7 abstracts)
Influence of diabesity in the visceral adipose tissue miRNA expression profile
Carmen Lambert 1 , Elsa Villa-Fernandez 2 , Ana Victoria García Gómez 3 , Miguel García-Villarino 4 , Sandra Sanz 5 , Raquel R. Uria 5 , Maria Moreno 5 & Elias Delgado 6
1Ispa, Endo, Oviedo, Spain 2Health Research Institute of the Principality of Asturias (Ispa), Endocrinology, Nutrition, Diabetes and Obesity Group (Endo), Oviedo, Asturias, Spain; 3Health Research Institute of the Principality of Asturias (Ispa), Oviedo, Asturias, Spain, Instituto de Investigación Sanitaria del Principado de Asturias (Ispa), Endocrinology, Nutrition, Diabetes, Obesity Investigation Group, Oviedo,Asturias, Spain; 4Health Research Institute of the Principality of Asturias (Ispa), Oviedo, Asturias, Spain; 5Health Research Institute of the Principality of Asturias (Ispa), Oviedo, Asturias, Spain, Asturias Central University Hospital. Oviedo, Asturias, Spain; 6Health Research Institute of the Principality of Asturias (Ispa), Oviedo, Asturias, Spain, Asturias Central University Hospital, Oviedo, Asturias, Spain, Endocrinology in Hospital Universitario Central de Asturias (Huca), Oviedo, Spain.
Influence of Diabesity in the visceral adipose tissue miRNA expression profile.
Background: The term diabesity arose in 2001 to refer to the coexistence of obesity (OB) and type 2 diabetes (T2D). It is estimated that 89% of adults diagnosed with T2D have a BMI greater than 25 kg/m2, and of them, 45% are obese. However, the mechanisms because why some obese patients develop T2D and other do not, are still unclear.
Objectives: The principal objective of this work is to analysis the differential microRNA expression profile in the visceral adipose tissue (VAT) of obese patients regarding on the presence of T2D.
Methods: The miRNA expression profile of TAV from 48 patients (10 nonOb controls, 19 Ob_noT2D, and 19 Ob_T2D) was analyzed by NGS, identifying 288 different miRNAs. Among them, 12 miRNAs were selected for their validation by RT-PCR and their expression analyzed based on the presence of obesity and/or T2D.
Results: We observed that the miRNAs miR-200b-3p and miR-144-5p presented a differential profile between the 3 group of patients (Kruskal–Wallis test: P=0.002 and P=0.011 respectively). Additionally, miR-200b-3p, miR-144-5p, miR-335-3p and miR-224-5p were increased in the group of Ob_noT2D patients compared to those Ob_T2D, although only the first two showed a significant change (Dunn Post- Hoc test: P=0.001, P=0.011, P=0.068 and P=0.078 respectively).
Conclusions: Our study shows the influence of diabesity in the miRNA expression profile of VAT. A better understanding of the differences between the VAT of obese patients with and without diabetes can help to better understand the metabolism of diabesity, helping us to understand what causes an obese patient to develop DM2 or not.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more