Endocrine Abstracts

Background: Bisphenol A (BPA) acts as an endocrine disruptor in different endocrine systmes. However, its impact on the adrenal cortex and steroidogenesis is largely unknown. This also applies to its substitute substances bisphenol F (BPF) and S (BPS). Therefore, experiments addressing this subject are urgently needed.Methods: The human adrenocortical cell lines NCI-H295R and MUC-1 were treated with increasing concentrations (1 nM–1 mM) of bisphenol...

Background: Cell senescence is characterized by halted cell proliferation and the acquisition of a pro-inflammatory profile. Cancer cells can enter into senescent state following treatments that inflict DNA damage. Intriguingly, these cells can evade the senescent state, gaining enhanced proliferative capabilities and resistance to further treatment, thereby prompting tumor recurrence. Senolytics offer the potential to eradicate selectively senescent cells, preventing tumor re...

Background: Sport results might be influenced by advances in sport science leading to better training, but also by new knowledge of human physiology and endocrinology. Doping and its detection as well as impact of regulations like testosterone limitations for women category eligibility might be reflected in top sport performances.Objectives: We aimed to retrospectively analyse factors influencing top performances in short, middle, and long-distance runni...

Children born small for gestational age (SGA) not showing catch-up growth in early life may show decreased growth rate and adult height and worse metabolic profile compared to general population. In these patients, growth hormone (GH) treatment showed positive effects on growth rate and metabolic profile, with good tolerability. The aim of the study was to evaluate auxological and metabolic effects and safety of GH treatment in SGA children. Study included 34 SGA children (15 ...