Searchable abstracts of presentations at key conferences in endocrinology
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ESE Young Endocrinologists and Scientists (EYES) 2023

ESE Young Endocrinologists and Scientists (EYES) 2023

Oral communication 7: Diabetes, Obesity and Metabolism

ea0093oc43 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Statin use and perimenopausal BMI determine the risk of incident diabetes mellitus in the postmenopause: Results of Palladia study

Mavraganis George , Papanikola Nektaria , Angelopoulou Anastasia , Stefanaki Aikaterini , Armeni Eleni , Paschou Stavroula , Anelli Valentina , Augoulea Areti , Stamatelopoulos Kimon , Lambrinoudaki Irene

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

ea0093oc44 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Insulin secretion defect in children and adolescents with obesity: Clinical and molecular genetic characterisation

Enders-Seidlitz Helena , Raile Klemens , Galler Angela , Wiegand Susanna

Background: Childhood obesity is increasing worldwide and presents as a global health issue due to multiple metabolic comorbidities. About 1% of adolescents with obesity develop type 2 diabetes (T2D), however little is known about the genetic background in young age. The objective of this study was to assess the prevalence of impaired glucose regulation (IGR) in a large cohort of children and adolescents with obesity and to characterize insulin sensitivity and insulin secretio...

ea0093oc45 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Influence of diabesity in the visceral adipose tissue miRNA expression profile

Lambert Carmen , Villa-Fernandez Elsa , Gomez Ana Victoria Garcia , Garcia-Villarino Miguel , Sanz Sandra , Uria Raquel R. , Moreno Maria , Delgado Elias

Influence of Diabesity in the visceral adipose tissue miRNA expression profile.Background: The term diabesity arose in 2001 to refer to the coexistence of obesity (OB) and type 2 diabetes (T2D). It is estimated that 89% of adults diagnosed with T2D have a BMI greater than 25 kg/m2, and of them, 45% are obese. However, the mechanisms because why some obese patients develop T2D and other do not, are still unclear.Objective...

ea0093oc46 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Glycaemic and inflammatory profile changes in patients with hybrid closed loop systems

Gomez Ana Victoria Garcia , Alarcon Pedro Pujante , Villa-Fernandez Elsa , Goitia Carmen Lambert , Villarino Miguel Garcia , Irusta Alicia Cobo , Alvarez Elias Delgado

Background: the treatment of individuals with type 1 diabetes (T1D) has significantly evolved in recent years. Therefore, with the aim of achieving glycaemic targets to prevent or slow down the progression of the disease and its complications, hybrid closed-loop systems (AID) have been developed. These systems integrate three components: a continuous real-time glucose monitor, a control algorithm and an insulin pump. The objective of this study is to analyse the glycaemic and ...

ea0093oc47 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Amino acids and biogenic amines circadian fluctuation in health and in hypercortisolism states

Galante Greta , Tucci Lorenzo , Improta Ilaria , Bissi Valentina , Perrone Alessandro , Coscia Kimberly , Colombin Giacomo , Di Cintio Ilaria , Vicennati Valentina , Pagotto Uberto , Di Dalmazi Guido , Fanelli Flaminia

Background: Chronic hypercortisolism exhibits irregular circadian rhythm and deranged protein metabolism. Altered amino acid(AA) and biogenic amine(BA) circulating levels were found in patients with hypercortisolism. However, there is limited information about the physiologic circadian fluctuation of AA and BA levels, and it is not known whether this is affected by states of hypercortisolism.Aim: To characterize levels and daily fluctuations of AA and BA...

ea0093oc49 | Oral communication 7: Diabetes, Obesity and Metabolism | EYES2023

Effects of chronic pancreatitis in beta-cell function and incretin secretion

Ciccarelli Gea , Di Giuseppe Gianfranco , Soldovieri Laura , Brunetti Michela , Capece Umberto , Moffa Simona , Cinti Francesca , Giaccari Andrea , Mezza Teresa

Background: Chronic pancreatitis (CP) is the most frequent cause of diabetes of the exocrine pancreas (DEP). Although the specific alterations of DEP are not completely understood, individuals with DEP are considered affected by pancreatic endocrine insufficiency and treated with insulin. To investigate the functional alterations of DEP, we evaluated differences in glucose metabolism in patients with and without CP, classified according to their glucose tolerance (NGT, IGT, DM...