Endocrine Abstracts

Background: Thyroid hormones (THs) stimulate hepatic de-novo lipid biosynthesis but also lipolysis and beta-oxidation. Similarly, they simultaneously enhance cholesterol uptake, biosynthesis, and degradation. Thyroid hormone receptor beta (THRβ) is the main hepatic thyroid hormone receptor. Mammals have developed a circadian timekeeping system that controls physiological processes to adapt to time-of-day.HypothesisWe hypothesized that TH effects are subject to circadian r...

Ischemic heart disease (IHD) is one of the leading causes of death worldwide. TH have impact on cardiac function and even appear to improve outcome after acute ischemia/reperfusion and in chronic heart failure. This project aims to investigate the influence of TH receptor alpha (TRα) on IHD using specific mouse models to assess the contribution of canonical vs. non-canonical TH signaling. Mice underwent permanent ligation of the left descending coronary artery and were tr...

Background: and ObjectiveThyroid collision tumors are extremely rare, accounting for just around 1% of all thyroid carcinomas. The objective of this study is to enhance our understanding of the clinical characteristics of these infrequently reported occurrences. In our study, we evaluated the clinical features of medullary thyroid carcinoma (MTC) that existed synchronously with papillary thyroid carcinoma (PTC).Methods: We performed a retrospective anal...

Background: The combination of a toxic adenoma and Graves’ disease compose the Marine-Lenhart syndrome. It is estimated to occur in 0.8–2.7% of Graves’ disease and only few are reported.Case presentation: A 29-year old female was referred to our clinic due to subclinical hyperthyroidism and a newly discovered thyroid nodule on the right thyroid lobe. She had no thyreotoxic symptoms and the clinical examination was unremarkable. The blood t...