EYES2023 ESE Young Endocrinologists and Scientists (EYES) 2023 Oral communication 2: Neuroendocrinology (6 abstracts)
Psychopathological characteristics in patients with arginine vasopressin deficiency (central diabetes insipidus) and primary polydipsia
Julia Beck 1 , Cihan Atila 2 , Julie Refardt 2 , Zoran Erlic 3 , Juliana Drummond 4 , Beatriz Santana Soares Rocha 4 , Felix Beuschlein 3 , Bettina Winzeler 2 & Mirjam Christ-Crain 2
1University Hospital Basel, Department of Endocrinology, Diabetology and Metabolism, Basel, Switzerland; 2University Hospital Basel, Endocrinology, Basel, Switzerland; 3University Hospital Zürich, Department of Endocrinology, Diabetology and Clinical Nutrition, Zürich, Switzerland; 4Universidade Federal de Minas Gerais, Departamento de Medicina Interna, Faculdade de Medicina, Belo Horizonte, Brazil.
The differential diagnosis between arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus, and primary polydipsia (PP) is challenging. Psychopathologic findings are often used as a hallmark for diagnosing PP; thus. Yet, psychopathologic characteristics are barely assessed in patients with AVP-D, and to date, no data exist comparing AVP-D and PP with regard to these features. Therefore, in this study, we aimed to compare levels of anxiety, depression, alexithymia, and overall mental health in patients with AVP-D and PP. In total, 82 participants (n=39 with AVP-D, n=28 with PP, and n=15 healthy controls [HC]) underwent a psychological evaluation with standardized questionnaires. Anxiety levels were assessed using the State-Trait Anxiety Inventory, mood using the Beck’s Depression Inventory, alexithymia using the Toronto Alexithymia Scale, and overall physical and mental health using the Short Form 36 Health Survey (SF-36). Higher STAI, BDI, and TAS scores indicate higher anxiety, depression, and alexithymia levels. Higher SF-36 scores indicate better health and less disability. Compared with HC, patients with AVP-D and PP showed increased levels of anxiety (HC 28 points [24, 31] vs. AVP-D 36 points [31, 45], P<0.01; vs. PP 38 points [33, 46], P<0.01), depression (HC one point [0, 2] vs. AVP-D 7 points [4, 14], P<0.01; vs. PP 7 points [3, 13], P<0.01), and alexithymia (HC 30 points [29, 37] vs. AVP-D 43 points [35, 54], P<0.01; vs. PP 46 points [37, 55], P<0.01). Levels of anxiety, depression, and alexithymia showed no difference between patients with AVP-D and PP (P=0.58, P=0.90, P=0.50). This is the first study demonstrating comparable increased levels of anxiety, depression, alexithymia, and overall reduced mental health in patients with AVP-D and PP. Based on these data, psychopathological findings should not be used as a hallmark to differentiate between both conditions.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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