ETA2023 Poster Presentations Hypothyroidism (9 abstracts)
Liquid Levothyroxine (L-T4; vs. Tablet L-T4) mantains more stable tsh levels in hypothyroid patients
Poupak Fallahi 1 , Silvia Martina Ferrari 2 , Giusy Elia 3 , Francesca Ragusa 3 , Sabrina Rosaria Paparo 1 , Eugenia Balestri 3 , Chiara Botrini 3 , Armando Patrizio 4 , Valeria Mazzi 3 & Alessandro Antonelli 3
1University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy; 2University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy; 3University of Pisa, Department of Surgical, Medical and Molecular Pathology and Critical Area, Pisa, Italy; 4Azienda Ospedaliero-Universitaria Pisana, Department of Emergency Medicine, Pisa, Italy
Hypothyroidism is usually treated with levothyroxine (L-T4), that is present in different formulation. We aim to assess if hypothyroid patients have a better control of thyroid-stimulating hormone (TSH) levels by following a L-T4 therapy in a liquid formulation, with respect to the tablet formulation. We enrolled seven hundred hypothyroid patients treated with liquid L-T4, and three hundred and fifty hypothyroid subjects receiving tablet L-T4 (both groups were matched by age and gender). All the enrolled subjects had normal circulating TSH levels at the basal evaluation, and did not report any malabsorption or drug interference issues. Patients were monitored for two years, and their serum TSH, FT3, FT4 levels were assessed after one and two years. At the first abnormal TSH value, we evaluated: age, gender, body mass index, history of chronic autoimmune thyroiditis, initial TSH, and L-T4 dosage. At the time of initial normal TSH, these parameters were not significantly associated with time to abnormal TSH values. We registered the following results: after 1 year, TSH values were normal in 84 % of the patients who received L-T4 liquid formulation, and only in 77% of patients treated with tablet L-T4; after 2 years, TSH values resulted normal in 82% of patients receiving L-T4 liquid formulation, and only in 73% of those with tablet L-T4 (P < 0.05). Hypothyroidism affects approximately 5% of the population, mostly of them are women and people over 60 years of age. Once reached stable TSH levels in the normal range, patients are monitored with an annual test of the TSH levels in order to adjust the therapy, if necessary. The maintainment of a stable TSH level in the normal range is very important, since large population studies showed an increased mortality in people with TSH in the hypothyroid range. Our data support the efficacy of liquid L-T4, with respect to tablet L-T4, in the maintainment of normal TSH levels in hypothyroid patients in the long term follow-up.
Keywords: Hypothyroidism, liquid L-T4, tablet L-T4, Hormone Replacement Therapy, Thyroid
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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