Endocrine Abstracts

Introduction: It is well established fact that the thyroid gland and heart have diverged from the same ancestral origin, thus have close metabolic relationship. Any alteration in the thyroid hormone profile, either hyper or hypo thyroid conditions may lead to manifestation of cardiac diseases. In routine clinical procedures abnormalities in the thyroid hormone levels were commonly observed in the cases of chronic heart failures.

Objective: To Evaluate and compare pre/intra/post-operative parameters of subjects with/without thyroid undergoing CABG to study the impact of thyroid hormones on their post-operative outcomes.

Method: A tertiary care hospital-based study was planned to enroll the patients undergoing for the CABG. The subjects above the age of 18 years with Indian nationality were chosen for the study. The other inclusion criteria were subject undergoing CABG, able to give informed consent and free from other comorbid conditions including pregnancy. The study was approved by the Institutional Ethics Committee. Total 560 subjects were qualified for the study. Selected subjects were further divided into three groups (Hypothyroid, Hyperthyroid and Euthyroid) based on their thyroid hormone status after confirmation from practising endocrinologists. Their samples and data were collected and analysed using MS Excel and SPSS.

Results: The Euthyroid subject group has a mean value of 3 hours ICU stay which is less than the mean ICU stay of hypothyroid (5 hours) and hyperthyroid (4 hours). For the Euthyroid subjects average stay in the hospital was 10 days whereas for the group of subjects having thyroid, either hypothyroidism or hyperthyroidism the average length of stay in the hospital was for 12-14 days. Average ionotrope usage by Euthyroid group was 3.4 hrs whereas for hypothyroid and hyperthyroid group it was 3.8 hrs and 3.7 hrs respectively. Ventilator support needed by Euthyroid group was 16 hrs whereas for hypothyroid and hyperthyroid was 18 hrs.

Conclusion: The subjects groups without thyroid shows better post-operative outcomes as compared to the groups of subjects having altered thyroid status. Thyroidism, either hypothyroidism or hyperthyroidism impacts post-operative outcomes of subjects undergoing coronary artery bypasss surgery. Therefore, altered thyroid levels may be an indicator of poor outcomes post-surgery.