Endocrine Abstracts

Thyroid hormones influence other organs as well as nearly all parts of the human body, so thyroid hormone imbalance can cause diverse problems in the human body. Chronic rhinosinusitis (CRS) is one of the most common diseases among patients visiting otorhinolaryngology clinics, and CRS can be divided into two different subtypes: CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRS and thyroiditis are common diseases related to autoimmune features; however, there have been few studies on their correlation. The purpose of this study was to examine the relationship between thyroid conditions and CRS in a matched cohort in a study performed inside the Korean National Health Insurance Service-Health Screening Cohort (2002–2015). With 24,096 control individuals, 6024 CRS patients were 1:4 matched for age, sex, household income, and region of residence. Conditional logistic regression was used to examine the effects of a prior history of thyroid disease, including hypothyroidism, hyperthyroidism, thyroiditis, autoimmune thyroiditis, and Graves’ disease. Subgroup analyses were performed in regard to the presence of nasal polyposis. Univariate analysis (all P > 0.05) revealed that there was no difference between the CRS group and the control group in the prevalence of a history of hypothyroidism (2.8% vs. 1.8%), hyperthyroidism (2.0% vs. 1.5%), thyroiditis (1.1% vs. 0.8%), autoimmune thyroiditis (0.4% vs. 0.3%), and Graves’ disease (0.3% vs. 0.2%). In the multivariate-adjusted model, hypothyroidism was linked to CRS (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.00–1.57). After being categorized according to the presence or absence of nasal polyps, thyroid disorders were not statistically significantly linked with CRS in the subgroup analyses. Our study reported a statistically significant association between hypothyroidism and CRS. Future studies are required to fully elucidate the relationship between thyroid diseases and CRS, including the mechanisms underlying this association.