ETA2023 Poster Presentations Thyroid Cancer Diagnosis 1 (9 abstracts)
Clinical significance of tumor size in gross extrathyroidal extension to strap muscles(T3B) in papillary thyroid carcinoma
Joonseon Park 1 , Kwangsoon Kim 2 , Ja Seong Bae 3 & Jeongsoo Kim 4
1Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital, Surgery, Seoul, Korea, Rep. of South; 2College of Medicine, the Catholic University of Korea, Department of Surgery, Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital Seoul, Republic of Korea; Seoul St. Mary’s Hospital; Surgery, Seoul, Rep. of South Korea, Surgery, Seoul, Korea, Rep. of South; 3General Surgery, Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, Korea, Rep. of South; 4Department of Surgery, Catholic University of Korea College of Medicine, Seoul St. Mary’s Hospital Seoul, Republic of Korea; Seoul St. Mary’s Hospital; Surgery, Seoul, Rep. of South Korea, Department of Endocrine Surgery, Seoul, Korea, Rep. of South
Background: It has been studied that larger tumor size in T3b has a worse prognosis than T3b with smaller tumor size. The present study aims to compare the clinicopathological characteristics among modified T categories and clarify the significance of tumor size in T3b on the DSS of differentiated thyroid carcinoma(DTC).
Methods: A total of 6282 patients with DTC who underwent thyroid surgery at a single center were retrospectively analyzed. Patients with T1, T2, T3a, and T3b categories were included according to the 8th edition of the AJCC/UICC TNM staging system. In the modified T categories, T3b was divided into T3b-1 (≤2 cm) and T3b-2 (2–4 cm), and T3b-3 (> 4 cm). Disease-free survival (DFS) and Disease-specific survival(DSS) were compared among all T categories.
Results: In the total cohort of 6282 patients, T1, T2, T3a, T3b-1, T3b-2, and T3b-3 were 3353 (88.1%), 339 (5.4%), 39 (0.9%), 239 (3.8%), 90 (1.4%), and 20 (0.3%), respectively. There were no differences in DSS between T1 and T3b-1 (P = 0.319). However, there were significant differences in DSS between T2 and T3b-2, and between T3a and T3b-3 (P < 0.001, P = 0.001, respectively).
Conclusions: These results indicate that the tumor size of T3b may affect DSS, which decides AJCC/UICC TNM staging system. T3b(≤2 cm) showed no significant difference in mortality compared to T1. A modified stage that moves T3b(≤2 cm) to T1 and includes only T3b(>2 cm) to T3b may show more efficient performance than the current stage.Keywords: T3b, tumor size, modified T category, Differentiated thyroid carcinoma
Volume 92
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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