Endocrine Abstracts

Background: Over the last few decades, in vivo animal experiments have been the gold standard for the assessment of safety of chemicals and pharmaceuticals for human health. However, in vivo animal data has limited relevance for toxicity prediction in humans, especially considering species-specific issues of age, sex and exposure in different life-stages. Within the Virtual Human Platform for Safety Assessment (VHP4Safety) project we aim to develop an animal-...

Objectives: Machine perfusion may become a platform for cardioprotective approaches, enabling repair and reconditioning of donor hearts. Ischemic preconditioning (PC) is a powerful means of cardioprotection. Triiodothyronine (T3) is shown to repair the injured myocardium and recently this cardioprotective action was demonstrated in an ex vivo rat heart normothermic perfusion model. This study investigated potential effects of low-flow PC with and without T3 administration in a...

Background: Thyroid hormones are essential for normal development and metabolism. Their synthesis requires a normal function of thyroid follicular cells and adequate nutritional intake of iodine. Immortalized thyroid cell lines are widely used to study thyroid physiology and pathology. The best characterized and most widely used ones include the FRTL5 rat thyroid cell line and a derivative thereof, the PCCL3 cell line. A permanent human thyroid cell line is currently lacking. ...

Diabetic nephropathy (DN) and cardiomyopathy (DC) are two major complications of diabetes that account for over two thirds of deaths among diabetic patients. Our previous studies have shown that thyroid hormone (TH) signalling – in addition to its critical role in physiological growth and organ development – plays similar roles in pathological conditions that encompass cellular dedifferentiation, cyto-architectural reorganization and compensatory growth. Though the r...

As thyroid hormones (TH) are essential for the normal heart function, a low TH state in ischemic cardiovascular events is often correlated to a poor prognosis. While clinical and experimental data suggests that TH intervention in acute myocardial infarction might be beneficial, a detailed insight in the mechanisms on TH action in IR injury or post infarct recovery of the heart is still lacking. In this study, we examined the effect of thyroid hormone pre- and postconditioning ...

Please Development and preliminary characterization of a simple human thyroid organoid in vitro model for thyroid metabolism investigation For decades, in vitro studies of the thyroid have relied on thyroid-derived tumor cell lines, which are limited by their undifferentiated phenotype, lack of response to TSH, and chromosomal abnormalities. A viable alternative are monolayer (2D) cultures of primary thyrocytes isolated from histologically normal thyroid glan...

Obesity rate keeps growing worldwide and weighs heavily on the healthcare system because of the related metabolic disorders like diabetes. In addition to calorie-rich diet and sedentary lifestyle, environmental exposure to obesogens, endocrine disrupting chemicals (EDC) targeting adipose tissue and its function as well as central pathways regulating food intake and energy expenditure, could add to the raising obesity incidence. The flame-retardant tetrabromobisphenol A (TBBPA)...

Introduction: Forkhead box E1 (FOXE1) gene encodes a transcription factor crucial for thyroid morphogenesis, differentiation, and function. We previously found evidence of the involvement of a rare germline FOXE1 variant in familial non-medullary thyroid carcinoma (FNMTC) etiology. FNMTC most common subtype is papillary thyroid carcinoma (PTC), and family members frequently present thyroid follicular nodular disease (FND). Germline FOXE1 mu...

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...