Endocrine Abstracts

Objectives: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a validated and widely used tool for thyroid nodules triage. Studies reporting on the frequency of each Bethesda category are scarce, and there are wide discrepancies in the reported results between the various centers. Our aim was to register all cytological reports of the thyroid fine needle aspiration biopsies (FNAB) reviewed in the Cytology Department of a tertiary hospital during a calendar ye...

The diagnosis of indeterminate thyroid nodules is a challenge in cytopathology practice. To increase the diagnostic accuracy in these cases, we previously set up a ’thyroid risk score’ (TRS), derived from the sum of the scores assigned to: cytology + EU-TIRADS classification + nodule size + molecular profile. In the present study we prospectively validated the reliability of the TRS in the clinical practice. From 2018 to 2022 we evaluated 354 indeterminate nodules (2...

Background and Objective: In thyroid cancer (TC) central compartment (CC) neck dissection (CCND) should accompany thyroidectomy in case of clinical and/or cytological suspicion of lymph node (LN) metastases. Cervical ultrasound has been indicated as the first-line examination in the pre-operative staging of TC, although its diagnostic performance in evaluating CC LN is controversial. Proving that cervical ultrasound can accurately identify CC metastases would allow to use this...

Background: Patients with medullary thyroid carcinoma (MTC), a neuroendocrine tumour derived from the parafollicular C-cells, often present with metastasized disease. Survival strongly correlates with stage of disease at diagnosis, illustrating the need for early diagnosis. Calcitonin (CT), a well-established tumour marker for MTC, is limited by a high rate of false positives in the screening phase. Promising new markers for MTC are procalcitonin (PCT) and progastrin releasin...

Objectives: PET/CT scan with 18F-fluoro-dihydroxyphenylalanine (18F-DOPA) is an emerging useful tool in medullary thyroid cancer (MTC) patients. The question whether 18F-DOPA-PET/CT could be useful in MTC patients with biochemical incomplete response (BiR) is to clarify.Methods: Fifty-three MTC patients with BiR performed 18F-DOPA-PET/CT scan between May 2021 and December 2022 after having performed total body ...

Background: Presence of venous vascular invasion is a criterion of intermediate risk of recurrence in papillary thyroid carcinoma (PTC). However, the presence and type of vascular invasion (lymphatic or venous) is often underreported and its impact on PTCs without other risk features remains unknown.Objective: To evaluate the impact of both lymphatic and venous invasion on the risk of recurrence/persistence on otherwise low-risk PTCs.<p class="abstex...

Correlation of three thyroglobulin assays in the management of differentiated thyroid cancer (DTC) patientsIntroduction: Thyroglobulin(Tg) is the main biochemical marker of DTC. Usual immunometric assays(IMA) are prone to interference by autoantibodies which can lead to erroneous results. LC-MS/MS has been described as an assay that may provide accurate results, however the literature reported up to 40% of undetectable rates in patients with positive thy...

Objective: The prevalence of incidentally discovered papillary thyroid microcarcinoma (iPTMC) has increased with the expanded use of diagnostic imaging, including nuclear medicine imaging techniques. While iPTMC appears to have a better prognosis than non-incidental PTMC, it was suggested that thyroid carcinomas that were incidentally discovered during 18F-fluorodeoxyglucose positron emission tomography/computer tomography (FDG PET/CT) or parathyroid scintigraphy may have poor...

Introduction: Despite its neuroendocrine origin, only recently an international study group proposed a dedicated grading system (IMTCGS) for medullary thyroid carcinoma (MTC). IMTCGS is an independent and powerful tool able to predict disease specific survival (DSS) as well as distant metastasis-free (DMFS) and locoregional recurrence-free survivals (LRFS), regardless of other risk factors, including staging.Objectives: To evaluate the performance of IMT...