Endocrine Abstracts

Objectives: One of the risk-based screening criteria for thyroid disease in pregnancy is previous abnormal thyroid function or thyroid autoantibody-positivity. We speculated on the frequency and results of thyroid function testing in women of fertile age as part of routine care before and after a pregnancy.Methods: The North Denmark Region Pregnancy Cohort includes retrospective assessment of thyroid function and thyroid autoantibodies (ADVIA Centaur XPT...

Anti-thyroid antibody (ATA) positivity affects 1 out of 9 women in childbearing age and presents a significant risk for infertility. Emerging evidence indicates that alterations in the B cell receptor induced calcium (Ca2+) signaling could be key in the development of autoimmunity. We aimed to investigate the Ca2+ flux response of B lymphocyte subsets to BCR stimulation in Hashimoto’s thyroiditis and related infertility. We collected peripheral blood samples from ATA+, in...

Background: Graves’ hyperthyroidism is known to improve spontaneously during pregnancy due to immune tolerance, although postpartum worsening or relapse of hyperthyroidism is likely to occur.Objective: To investigate the prevalence of postpartum worsening of Graves’ orbitopathy (GO) in relation to thyroid dysfunction.Methods: This was a retrospective cross-sectional study that included 8594 patients with Graves’ dise...

Background: The introduction of newborn screening for congenital hypothyroidism (CH) has led to prevent the most serious consequences of precocious deficit of thyroid hormone during child development, particularly neurological disability. However, little is known about long-term physical and psycho-social outcomes of CH after screening introduction.Objective: To evaluate physical and neuropsychological development and Quality of Life (QoL) in adult subje...

Background and Objectives: During pregnancy normal thyroid activity undergoes significant changes, including an increase in the amount of iodine intake and maternal renal iodine excretion. Hence, dietary iodine requirements are higher in pregnant women than in non-pregnant ones. This study aimed to assess the nutritional iodine status in a large group of pregnant women and thyroid function according to different iodine intake and thyroid diseases.Methods...

Background and objectives: Recent data on median urinary iodine concentration (UIC) in schoolchildren showed that Italy has achieved iodine sufficiency. Nevertheless, no national data on iodine nutrition in pregnancy are available. Therefore, a multicentre study coordinated by the Italian National Observatory for Monitoring Iodine Prophylaxis (OSNAMI), was launched in 8 Italian regions representative of the Northern (Lombardy, Veneto, Liguria), Central (Tuscany, Lazio) and Sou...

In the last 20 years an increasing number of European patients with autoimmune thyroiditis are supplemented with selenium in case of elevated thyroid autoantibody levels. However, a multicenter research trial in the United States suggested that selenium supplementation might increase the incidence of type 2 diabetes. The aim of this small study was to assess whether selenium supplementation in patients with autoimmune thyroiditis has any effect on carbohydrate metabolism witho...

Introduction: Pregnancy is a test for the thyroid, which has many physiological adaptation mechanisms to increased hormonal needs and iodine depletion. These changes expose the pregnant woman to dysthyroidism not devoid of maternal and fetal consequences. The prevalence of clinical and subclinical thyroid insufficiency in pregnant women are 0.3 to 0.7% and 2.2 to 2.5%, respectively. The objective of this study is to evaluate the thyroid status in a population of diabetic pregn...

Thyroid hormones measure is inevitable in some critically ill patients and may help the management. Alternatively, the physiological changes in the thyroid imbalance during pregnancy also make establishing reference intervals for critical ill challenging.Objectives: We aimed to compare reference intervals in an obstetric intensive care unit.Methods: After excluding patients admitted after delivery or pregnant under thyroid disease ...