Endocrine Abstracts

The documentation of goiter as a swollen neck is well known in the history before its medical description. Artists depicted what they saw in humans, the swollen human neck was the norm in many areas with endemic goiter in old Egypt, Greece, South America, and mountainous areas in central Italy and Switzerland. Sculptures from the ancient civilizations clearly demonstrated endemic goiters and cretinism in areas of environmental iodine deficiency. The engraved stones in old Egyp...

Introduction: The use of iodinated contrast media (ICM) can lead to thyrotoxicosis, especially in patients with risk factors, such as Graves’ disease, multinodular goiter, older age, and iodine deficiency. Although hyperthyroidism may have clinically relevant effects, whether high-risk patients should receive prophylactic treatment before they are administered ICM is still debated.Aim of the study: We aimed to demonstrate the safety and efficacy of ...

Objectives: The use of thyroid hormones (TH) to treat obesity is not supported by evidence based on efficacy and safety, and this is reflected in recommendations of major international guidelines on hypothyroidism and obesity. We aimed to explore views about this practice among European thyroid specialists and their associations with respondent characteristics.Methods: Thyroid specialists from 28 countries were invited to participate in a questionnaire s...

Introduction: Immune checkpoint inhibitors (ICIs) are an effective treatment for advanced cancer, but they are not free from immune-related adverse events (irAEs). A common irAES is thyroid dysfunction (TD-irAEs) and, as such, may influence patient survival and response to ICIs.Objetives: The aim was to determine the incidence and characteristics of TD-irAEs among patients with advanced cancer treated with ICIs in a real-life setting and to investigate t...

Background: Radiotherapy (RT) with or without chemotherapy is a common treatment for head and neck squamous cell carcinoma (HNSCC) patients and it can cause adverse effects, including dysfunctions of thyroid. The aim of this study was to identify thyroid dysfunction among patients submitted to external RT for treatment of HNSCC, with serial evaluation of thyroid function.Material and methods: This is a retrospective longitudinal study of the follow-up of...

The Case Study: We report the case of a 68-year-old female referred to the E.R. department with severe neurological problems. Patient’s neurological status revealed that patient was disoriented in time and place, with emotional irritability and an asymmetric eye fissure, and not feeling well without any obvious reason. A preliminary CT scan with I/V contrast was done and acute neurological damage was excluded. In the lab, there were: hypokalemia, hypomagnesemia, increased...

Introduction: The relationship between thyroid function and obesity and associated metabolic parameters has been extensively investigated especially in patients with primary hypothyroidism on levothyroxine replacement therapy. Current data show inconsistent results possibly influenced by some patients’ characteristics such as sex, age, concomitant diseases and medications.Objective: To assess the relation between thyroid function tests and BMI, fast...

Objectives: Immune checkpoint inhibitors (ICIs) have demonstrated stunning effects in many cancer types albeit its immune-related adverse outcomes such as hypophysitis, adrenalitis, and thyroiditis. Despite the significant increase in ICIs use in Korea, there still is a lack of clarification about the actual prevalence and risk factors of ICI-associated thyroid diseases.Methods: In this nationwide cohort study, 12,079 lung cancer patients were extrapolat...

Background: Iodine nutrition relies on dietary intake. Marine foods are iodine rich, and they contributed markedly to the iodine intake among populations in Greenland. However, dietary habits are drifting away from the traditional diet dominated by iodine rich marine foods such as seal, whale, and seabirds. This led us to monitor iodine nutrition among populations in Greenland.Methods: Cohort studies were conducted in 1998, 2008, and 2018 including 50-69...