Endocrine Abstracts

Background: Levothyroxine (LT4) is considered the standard of care for hypothyroidism, however 5-10% of hypothyroid individuals complain of persistent symptoms despite achieving biochemical euthyroidism on LT4.Methods: 17,247 thyroid specialists from 28 countries were invited to participate in a survey. It enquired about respondents’ perceptions of the cause of hypothyroid-like persistent symptoms and how the prevalence of such complaints had change...

Background: Levothyroxine (LT4) monotherapy is the mainstay of treatment of hypothyroidism, but a sizeable minority of endocrinologists also use T3-containing treatments in some patients notwithstanding concern about their safety.Methods: 17,247 thyroidologists from 28 countries were invited to participate in a questionnaire survey. Geographic regions were defined according to the UN Statistics Division. Gross national income (GNI) information stems from...

Objective: Hypothyroidism is one of the most common disturbances of thyroid function caused by a thyroid hormone deficiency, found predominantly in young women. The general slowdown of metabolic processes and low-grade chronic inflammatory state occurs in the broad spectra of clinical hypothyroidism manifestations. Although several risk factors of hypothyroidism have been identified, the exact pathogenic mechanisms remain unexplained. The conventional treatment of hypothyroidi...

Background: Autoimmune thyroid diseases (AITD) are multifaceted conditions in which the thyroid gland is infiltrated by lymphocytes resulting in the production of thyroid-specific auto-antibodies against thyroid peroxidase (TPOAb) and thyroglobulin (TGAb). Iron deficiency (ID) is considered to be the most common nutritional deficiency worldwide and has multiple effects on thyroid metabolism.Aim: The goal of this study is to measure the prevalence of auto...

Thyroid hormones (TH) are responsible for maintaining metabolism. Its concentrations are fundamental during pregnancy and the first days of life, and its imbalance can generate early and late repercussions for the newborn.Objectives: This study evaluates the relationship between maternal thyroid disease history impact on newborns and infants admitted to the semi-intensive care unit.Materials and methods: Data were collected from a ...

Hypothyroidism is usually treated with levothyroxine (L-T4), that is present in different formulation. We aim to assess if hypothyroid patients have a better control of thyroid-stimulating hormone (TSH) levels by following a L-T4 therapy in a liquid formulation, with respect to the tablet formulation. We enrolled seven hundred hypothyroid patients treated with liquid L-T4, and three hundred and fifty hypothyroid subjects receiving tablet L-T4 (both groups were matched by age a...

Background: Whether combination therapy of levothyroxine and liothyronine increases the risk of atrial fibrillation remains a topic of debate.Objectives: The objective of this study was to investigate the risk of atrial fibrillation in individuals with hypothyroidism treated with a combination of levothyroxine and liothyronine.Methods: We conducted a retrospective cohort study using individual-level linkage of Danish nationwide reg...

Introduction: Consumptive hypothyroidism is a rare condition characterized by the aberrant expression and increased activity of thyroid hormone deiodinase type 3 (DIO3) in neoplastic tissue. This leads to an augmented conversion of thyroxine (T4) to the inactive reverse triiodothyronine (rT3). So far, most cases of consumptive hypothyroidism have been described in infants with hemangiomas.Case presentation: We report the case of a 64-year-old woman with ...

Tablet levothyroxine (L-T4) is the common treatment for hypothyroidism. We aim to investigate the efficacy of L-T4 in liquid formulation in patients recently subjected to total thyroidectomy (without malabsorption or drug interference), with respect to L-T4 tablets. Eighty patients were treated with L-T4 in tablets, whereas one hundred and sixty received liquid L-T4 at the same dosage (1.5 mg/kg/day). All patients started the therapy the day after thyroidectomy, and the drugs ...