Endocrine Abstracts

Objectives: Some evidence suggests gene-treatment interactions might cause persistent symptoms in individuals receiving levothyroxine (LT4) treatment. We investigated, as previously hypothesized, if single nucleotide polymorphisms (SNPs) in rs225014 (Thr92Ala), rs225015, or rs12885300 (ORFa-Gly3Asp) in the Deiodinase 2 gene (DIO2), or rs17606253 in the Monocarboxylate Transporter 10 gene (MCT10) were associated with outcomes indicative of local tissue hypothyroidism in LT4-tre...

Objectives: The insulin-like growth factor I receptor (IGF-1R) plays a significant role in the pathology of thyroid eye disease (TED), an autoimmune disorder characterized by orbital inflammation. Teprotumumab, a human monoclonal antibody targeting IGF-1R, has demonstrated efficacy in treating moderate-to-severe TED. A significant proportion of patients experienced adverse events (AEs), with 74% and 85% reporting an AE and 12% and 5% reporting serious AEs in Phase 2 and 3 tria...

Background: Little is known about the long-term outcome of the thyroid function in Graves’ disease in a large epidemiological setting.Objective: The aim was to evaluate the long-term outcome of the thyroid function in patients diagnosed with Graves’ disease in Denmark in the period 1995-2018. Our research objectives were to investigate the incidence of disease, use of antithyroid drugs, radioactive iodine, thyroidectomy and levothyroxine during...

Introduction: Maternal thyroid function in early pregnancy is crucial for fetal neural development. Early offspring language acquisition is an important indicator of fetal neural development and a predictor of future cognitive development. We aimed to investigate how the mother’s thyroid function and the presence of thyroid autoimmunity in early pregnancy are associated with offspring’s language acquisition at the age of 12-37 months.Methods: T...

Introduction: The surgical approach is the first line treatment for patients with an indeterminate nodule, both without and with nuclear atypia (TIR3A and TIR3B, respectively, as defined by Italian Consensus for thyroid cytology). However, there are no prospective studies about the feasibility of active surveillance in patients with indeterminate thyroid nodules.Methods: Eighty-six consecutive patients who decided to undergo active surveillance for at le...

Background: Differentiated thyroid carcinoma (DTC) survivors have an increased risk of cardiovascular mortality but, the pathophysiological mechanism remains largely unknown. Early treatment for high-risk DTC entails thyroid surgery, radioiodine therapy with thyroid hormone (TH)-withdrawal, and thyroxine suppression therapy (THST). During treatment, patients cycle from severe hypothyroidism to exogenous subclinical hyperthyroidism. TH changes in early DTC treatment might affec...