Endocrine Abstracts

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disease worldwide. Prevalence of celiac disease (CD) is higher in HT patients and HT is the most prevalent coexisting disease in CD patients. In the last years, interest about gluten free diet (GFD) has increased for its supposed extraintestinal anti-inflammatory effect, so many patients with HT initiate GFD on their own.Objectives: Aim of this meta-analysis is to examine all qua...

Background: The association of autoimmune thyroiditis (AIT) with nonendocrine autoimmune disorders has been reputed for long time as a variant of type 2 polyglandular autoimmune syndrome (PAS2). Nowadays, it is framed in the picture of polyautoimmunity and its relevance is owed to its prevalence, far higher than PAS 2, and its expanding galaxy. Systematic studies on this field are rather scanty and mostly based only on the presence of circulating antibodies. Our study has been...

Objectives: Triiodothyronine (LT3) administration for 48hours in patients undergone primary angioplasty showed favourable effects on cardiac function and remodelling early after myocardial infarction (Thy-Repair, EudraCT 2016-000631-40, Thyroid 2022 Jun;32(6):714-724). The present study investigated whether this beneficial effect was dependent on the severity of infarct size. The extent of infarct size is one of the main determinants of morbidity and mortality after myocardial...

Objectives: Hyperthyroidism has been linked to long-term cardiovascular and metabolic morbidity and increased mortality. Current evidence indicates differential cardio-metabolic effects from antithyroid drugs (ATD) and definitive treatment options (radioiodine or thyroidectomy). We aimed to assess differences in mortality and cardiometabolic outcomes depending on treatment modality to better inform patient-clinician decision-making.Methods: We identified...

Background: Previous genetic and animal studies implied a potential association between thyroid hormone and osteoarthritis (OA), but this has not been confirmed in the general population. We aim to investigate whether thyroid function is associated with hand, hip or knee OA.Methods: We included 9,054 participants from Rotterdam Study with baseline measurement of thyroid-stimulating hormone (TSH), free thyroxine (FT4) and radiographs. Joint radiographs we...