ECE2023 Poster Presentations Thyroid (163 abstracts)
Assessement of Thyroid Function in An Obese Population
Chaima Jemai 1 , Manel Jemel 2 , Radhouen Gharbi 2 , Hajer Kandara 2 , Ines Kammoun 2 , Olfa Berriche 3 , Faten Mahjoub 4 & Henda Jamoussi 4
1National Institute of Nutrition of Tunis, C, Tunisia; 2National Institute of Nutrition of Tunis, B, Tunisia; 3National Institute of Nutrition of Tunis, A; 4National Institute of Nutrition of Tunis, A, Tunisia
Background: Obesity is an expanding pathology in the world and in Tunisia. We conducted this study to assess the thyroid function in a population of obese women and to investigate the relationship of thyroid status parameters with clinical and metabolic parameters.
Methods: This is a cross-sectional retrospective study about 50 obese women carried out at the obesity unit of department A of the National Institute of Nutrition in Tunis. We collected body mass index (BMI), waist circumference (W), serum free thyroxin (FT4) and thyroid stimulating hormon (TSH) levels, fasting glycemia (FG), baseline insulinemia, lipid profile, liver function, and body composition assessed by bioelectrical impedancemetry. We assessed insulin resistance and pancreatic activity by calculating the Homeostasic Model Assessment for Insulin Resistance (HOMA-IR) and the Homeostasic Model Assessment to quantify Beta-cell function (HOMA-B) respectively.
Results: The mean BMI and W were 41,2±9,3 kg/m2 and 120±17,7 cm respectively. The mean body fat percentage (BF) was 43,4±7,1%. The mean FT4 and TSH levels were 16,6±4,7 pmol/l and 2,4±1 IU/l, respectively. 2 patients had subclinical hypothyroidism. Glycoregulation abnormalities were noted in 54%. The mean insulinemia, HOMA-IR and HOMA-B were 23,4±14,8 mIU/l, 6,5±5,1 and 230,4±162,1 respectively. 96% (n=48) had insulin resistance. TSH was not correlated with cardiometabolic risk parameters nor with BF. FT4 was correlated with age (r=-0,3, P=0,017), FG (r=-0,29, P=0,019), insulinemia (r=-0,42, P=10-3), choesterol (r=0,24, P=0,04) and high density lipoprotein (r=0,24, P=0,002). It was not correlated with BF (r=-0,14, P=0,32).
Conclusion: In our population of obese women, FT4 seems to be more correlated than TSH with cardiometabolic risk parameters.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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