Endocrine Abstracts

Introduction: Hodgkin lymphoma is a cancer that affects the lymphatic system. Treatment includes chemotherapy and radiation therapy, which can increase the risk of secondary cancers such as thyroid and ovarian carcinomas. We report a case of a patient who developed secondary thyroid and ovarian cancers after being treated for Hodgkin’s disease.

Observation: Mrs LS was diagnosed with Hodgkin disease at the age of 34 and was treated with chemotherapy and radiation therapy of the neck and supraclavicular regions, achieving full remission. Ten years later, a full-body CT scan revealed a left latero-uterine pelvic mass of the ovary, which was diagnosed as ovarian small cell carcinoma after surgery. The patient received chemotherapy as adjuvant therapy. At the age of 49, the patient consulted for a left cervical swelling. Cervical ultrasound showed a 10 mm thyroid nodule Tirads 5, with malignant cytology (Beteshda 6). The patient underwent total thyroidectomy and central lymph node dissection. Histology revealed papillary thyroid carcinoma classified as pT1aN1bMx. The patient was referred to nuclear medicine. She received a 30 mCi Radioactive Iodine Treatment. Post-therapy whole-body scan showed mild iodine uptake in the thyroid bed.

Conclusion: The patient’s history of receiving radiation therapy for Hodgkin disease may have increased her risk of developing these secondary cancers. This case highlights the importance of long-term follow-up for patients treated by radiation therapy.