Endocrine Abstracts

Hashimoto disease, a chronic autoimmune lymphocytic thyroiditis, is the most common cause of hypothyroidism with a prevalence of 10–12% in the general population. Literature data suggests that persistently high levels of oxidative are considered as relevant risk factor in the occurrence and development of autoimmune diseases, including Hashimoto. The DNA and RNA are particularly valuable to the oxidative damage, and guanine is the most prone base to oxidation. Thus, the DNA/RNA repair processes are also activated by the formation of oxidants multiple guanine species, including 8-hydroxyguanosine (8-OHG), 8-hydroxy-2’-deoxyguanosine (8-OHdG), and 8-hydroxyguanine. Thus, the measurement of DNA/RNA oxidative damage, when all three oxidized guanine species; 8-hydroxy-2’-deoxyguanosine from DNA, 8-hydroxyguanosine from RNA, and 8-hydroxyguanine from either DNA or RNA would be quantify, may comprehensively determine the oxidative stress impact on nucleic acids damage and indirectly determine the level of activation of DNA/RNA repair processes. Determining the impact of oxidative stress on the development of autoimmune diseases is of great clinical importance, enabling the determination of new medical targets through the potential antioxidant implementation. Thus, the aim of the study was to evaluate the concentration of DNA/RNA oxidative stress damage products among Hashimoto’s patients in comparison to healthy subjects. For the purpose of this study, 50 patients with Hashimoto disease (study group) and 30 healthy volunteers (control group) were enrolled. The DNA/RNA oxidative stress damage products were evaluated using immunoassay method. The DNA/RNA oxidative stress damage products concentration was increased among study group comparing to control group. This may lead to the Hashimoto patients’ susceptibility to other diseases, including an increased risk of other autoimmune diseases or cancer. Thus, antioxidant intervention in these patients may bring many promising results, but many research in this field is still needed.