Endocrine Abstracts

Introduction: hypothyroidism is among the most frequent causes of infertility, our objective is to analyze this population in order to evaluate the effectiveness of treatment with levothyroxine.

Patients and methods: this is a retrospective interventional study from September 2017 to September 2022.

Inclusion criteria: infertility, TSH>2.5 mmol/l

Exclusion criteria: infertility for less than 1 year, age ≥ 45 years, other cause of infertility for the woman, spermogram abnormality.

Results: our work brought together 82 patients, 41% of whom presented with primary infertility, with an average age of 33 years. 32% have positive Anti TPO Abs, and 40% have a family history of thyroid disease. 33% of patients have a TSH (2.51-4.5), 51% TSH (4.51-10), 16% a TSH>10. Targeting a TSH ≤ 2.5 mmol/l improves the fertility rate by 56% with an average duration of 7 months under levothyroxine. There were 3 cases of abortion or stillbirth, this improvement in fertility is 48% in patients with TSH (2.51-4.5), 62% for TSH (4.51-10), 62% for TSH> 10.56% in patients with positive Anti TPO Ac, and 67% in patients with negative Anti TPO Ac.

Conclusion: our work shows that the use of levothyroxine in patients who consult for infertility with a TSH>2.5 mmol/l clearly improves fertility independently of the level of TSH and Anti-TPO Ac.