ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Endocrine and Non-Endocrine Causes of Fatigue in Adults With Turner Syndrome: Cohort Study and Review of the Literature
Anna Rosenberg 1 , Veerle D.A. Dingemans 1 , Anja Roubos 2 , Sanne Luijks 3 , Arianne B. Dessens 4 , Ramon Dykgraaf 3 , Jolien W. Roos-Hesselink 5 , Elisabeth van Rossum 1 , Aart Jan van der Lely 1 & Laura De Graaff 1
1Internal Medicine, division of Endocrinology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; 2Center of Excellence for Neuropsychiatry, Vincent van Gogh, Venray, Netherlands; 3Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; 4Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC, University Medical Center, Rotterdam, Netherlands; 5Department of Cardiology, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Background: Turner syndrome (TS) is a rare genetic developmental disorder characterized by gonadal dysfunction, short stature and heart defects, among others. Women with TS often suffer from severe fatigue, for which they are typically referred to endocrinologists. The diagnostic work-up is generally time-consuming and invasive, but it rarely solves the problem. To prevent the personal and financial burden of unnecessary diagnostic procedures, it is crucial to understand fatigue in TS. Therefore, in this study, we explored the association between fatigue and endocrine and non-endocrine comorbidities in a – for rare disorders – large group of TS women.
Design: Cross-sectional study.
Methods: 170 genetically confirmed TS women who attended the TS reference center underwent a systematic health screening, including a structured interview, complete physical examination, biochemical measurements, perceived stress and fatigue questionnaires and additional tests when indicated.
Results: Median age was 32.6 years (IQR 23.9 – 41.4 years) and median BMI was 25.4 kg/m2 (IQR 22.6 – 28.5 kg/m2). One in three TS women experienced severe fatigue. Liver enzyme disturbances and body mass index were significantly associated with higher fatigue scores, while childhood growth hormone treatment was associated with lower fatigue scores. Perceived stress was highly correlated with fatigue (ρ = 0.71; P<0.001).
Conclusions: There was no association between fatigue and most endocrine and non-endocrine disorders, which implies that fatigue is only partly explained by somatic disorders. The high correlation between perceived stress and fatigue suggests that TS-specific neuropsychological processes may play an important role in the etiology of fatigue in TS women. We provide a practical algorithm for the endocrine, non-endocrine and psychological approach to fatigue in TS women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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