Endocrine Abstracts

Objective: Migraine is a common primary headache disorder that affects 12-15% of the general population. Also, vitamin D deficiency is a global health problem. A few studies have shown relationship between serum vitamin D levels and headache. The aim of this study was to investigate the difference in serum levels of 25-Hdroxy vitamin d [25(OH)D] between migraine patients and healthy controls and also to determine the relationship of vitamin D deficiency with frequency and severity of migraine.

Materials and Methods: 204 newly diagnosed migraine patients and age- and sex- matched 204 control subjects were enrolled in this case -control study. Migraine diagnosis was settled according to the International Classification of Headache Disorders-III diagnostic criteria. The demographic and clinical data (migraine subtypes, frequency and severity of migraine) of the participants were recorded. Blood samples were obtained and 25(OH)D serum concentrations were determined using enzyme-linked immunosorbent assay (ELISA). Serum 25(OH)D ≤ 20, 21-29 and ≥30 ng/ml were considered deficient, insufficient, and sufficient, respectively.

Results: The mean concentration of 25(OH)D was 15.30± 9.93 ng/ml in migraine group and 14.62± 7.93 in controls. There was no significant difference in 25(OH)D concentration between migraine group and controls (P=0.443). There was no correlation between 25(OH)D level and headache characteristics including aura, attack severity and frequency (P>0.05). The number of subjects with vitamin d deficiency and insufficiency was similar between migraine group and controls (P=0.365).

Conclusions: We did not find significant difference in vitamin D levels among between case and controls. Also no significant correlation was noted between headache parameters (frequency and severıty) and serum vitamin D levels. Further studies with larger sample sizes are required to confirm our results.