ECE2023 Poster Presentations Late-Breaking (40 abstracts)
AMH in men: Higher serum levels associated with healthy male aging
Veronika Tandl 1 , Christoph W. Haudum 1 , Katharina Eberhard 2 , Barbara Hutz 1 , Ewald Kolesnik 3 , Albrecht Schmidt 3 , Andreas Zirlik 3 , Dirk von Lewinski 3 , Daniel Scherr 3 , Nicolas Verheyen 3 , Thomas R. Pieber 1 & Barbara Obermayer-Pietsch 1
1Medical University of Graz, Department of Internal Medicine, Division of Endrocrinology and Diabetology, Graz, Austria; 2Medical University of Graz, Core Facility Computational Bioanalytics, Graz, Austria; 3Medical University of Graz, Department of Internal Medicine, Division of Cardiology, Graz, Austria
Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male population and explore their relationship to various health parameters referring to potentially underlying (patho-)physiology. Out of the ongoing prospective BioPersMed cohort (Biomarkers for Personalized Medicine), we included male volunteers with available serum AMH measurements for cross-sectional (n=379) and longitudinal analysis (n=320) analysis over 3.8±1.2 (max 6.8) years. AMH and metabolic, hormonal, reproductive, and functional muscle parameters, as well as DXA-derived (dual energy X-ray absorptiometry) body composition were explored. AMH values were log-transformed for the statistical analyses, adjusted R2 values are given. In our cohort, median age was 59 years (IQR=13) and median serum AMH levels ranged from 0.07 to 23 ng/ml (median=4.75; IQR=4.02). An initial forward stepwise linear regression model included follicle stimulating hormone (FSH), estradiol (E2), total lean mass and mean handgrip values to best explain the variance of AMH levels (R2=0.217). There was an inverse relationship of AMH and age (R2=0.021; β=-0.004; P=0.003). In >75% of participants, AMH levels decreased during follow-up. FSH was the most powerful predictor (R2=0.159; β=-0.017; P<0.0001) of AMH. When both age and FSH were included in a model (R2=0.162), age was no longer significant (P=0.153), in contrast to FSH (P<0.0001). AMH decreased with BMI (R2=0.044; β=-0.01; P=0.002), but lean mass yielded a better fit (R2=0.065; β=-0.008; P<0.001) than BMI or fat mass. Including both parameters (R2=0.062), the relationship with BMI was no longer significant (P=0.7) other than with lean mass (β=-0.007; P=0.006). E2 was inversely correlated to AMH levels (R2=0.049; β=-0.003; P<0.0001), remaining significant after including potential confounders. The positive relationship of AMH and mean handgrip (R2=0.009; β=0.001; P=0.048) stayed significant when included in a model with both lean mass and FSH (R2=0.19; β=0.002; P=0.003). The age-dependent parameters FSH, E2, handgrip strength and lean mass were significantly related to AMH levels. Lean mass, as a proxy of blood volume, was a better predictor than BMI, suggesting some dilution effect. In summary, we found higher AMH levels being an interesting marker for healthy aging in males.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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