Endocrine Abstracts

Background: Thyroid cancer have good global prognosis with survival rate exceeding 85% at 5 years. Survivors are exposed to higher cardiovascular morbidity and mortality than the general population. The objective of this study is to quantify the prevalence of cardiovascular health levels in an Algerian cohort of thyroid cancer survivors who were considered free of any classical cardiovascular risk factors or cardiovascular disease

Methods: A cohort of patients followed in the thyroid cancer, and not known or treated for any cardiovascular risk factor or cardiovascular disease, has been screened for cardiovascular risk factors during the period between January 2020 and June 2021. Patients have received a complete evaluated, including three measures of blood pressure, BMI, fasting blood sugar, complete lipid profile, TSH, and FT4, in addition to smoking habits. The prevalence of 6 out of 7 cardiovascular risk factors of the American Heart Association (AHA)’s cardiovascular health (CVH) have been evaluated including nonsmoking, body mass index <25 kg/m², physical activity, untreated total cholesterol <200 mg/dl, untreated blood pressure <120/<80 mm Hg, and fasting blood glucose <100 mg/dl.

Results: 229 patients have been included, median age was 41 years (11-78), median time from diagnosis was 30 months (1-240), 86.5% were females, thyroid cancer type was as fellow respectively; 74%,3% and 12% for papillary, follicular, and medullary thyroid cancer. 83.3% were in stage 1 and 6.6% were in stage 2 according to AJCC 8^th edition, and 6.1% had metastasis. All patients were on levothyroxine with median TSH 0.28 at mui/ml. 55.5% of patients have received radioiodine therapy. Only 16.7% have a biological or radiological persistent/recurrent disease. Cardiovascular health level was as fellow; BMI <25 in 28.7% of patients, 59.6% of patients had fasting blood glucose<100d/dl, 64.6% had total cholesterol <200 mg/dl, 33.8% had systolic blood pressure <120 mmhg, 48.1% had diastolic blood pressure <90 mmhg, and 29.2% had blood pressure <120/<80 mm Hg, 11% of survivors made physically active and 96.9% were not smoking. no patient had all the factors in the objective

Conclusion: In this cohort of Algerian thyroid cancer survivors, the prognosis of cancer is favorable in most cases but the achievement of cardiovascular health is far from being reached. More efforts must be implemented to improve the cardiovascular health of thyroid cancer survivors.