Endocrine Abstracts

Introduction: Coronavirus infection COVID19 spread by Sars-Cov-2 virus were announced by WHO as a pandemics in the end of 2019. As shown in many studies virus affects whole body, particularly endocrine system. There were information about thyroid disturbances after COVID19 infection. Fergana valley of Uzbekistan is an endemic region with high degree of iodine deficiency. The aim of our study were investigate impact of COVID19 on thyroid function in people living in iodine deficiency region.

Material and methods: Study conducted in 84 people who had no any problems with thyroid gland previously and were admitted and treated from COVID19 in hospital of Fergana region. Patients’ clinical and anamnestic data, also data from charts were collected and analyzed. Thyroid gland were observed by palpation, thyroid hormones TSH, T3, free T4, and anti-TPO level were detected by RIA kits, structure of thyroid gland were estimated by ultrasound.

Results: 80% of observed people who were suffered from COVID19 were women and 20% were men. Palpation of thyroid gland shown that all of them had enlargement of thyroid gland (5%) or/and nodules (95%). Thyroid gland examination by ultrasound revealed that 30 (35%) patients had I-II degree of thyroid enlargement, 35 (42%) patients had autoimmune thyroiditis, 19 (23%) patients had nodular goitre. When examine the thyroid hormones level were shown that 58% patients were in euthyroid state, 36% patients had subclinical hypothyroidism, and 6% patients had manifest hypothyroidism. It seems that iodine deficiency more predisposed thyroid gland to Sar-Cov-2 virus.

Conclusion: In people who lives in high iodine deficiency region after COVID19 thyroid status were affected in 42% and structure were affected in all patients, where 35% was thyroid gland enlargement and in 42% had autoimmune thyroiditis and 23% had nodular goiter.