Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is typically characterized by elevated serum calcium associated with elevated or non-suppressed levels of parathyroid hormone (PTH). These biochemical features are both known to affect the cardiovascular (CV) system. There is a conflicting debate regarding the CV manifestations of PHPT. the aim of our study is to evaluate the cardiovascular profile in patients with PHPT.

Methods: We conducted a retrospective descriptive study at the military hospital of Tunis including 32 patients hospitalized for the management of PHPT. Clinical and paraclinical data were collected from medical records.

Results: Our population consisted of 13 men and 19 women with a mean age of 59,4 ± 13 years old. Hypertension, type 2 diabetes and dyslipidemia were found in respectively 31%, 21% and 6% of cases. Our patients were smokers in 12% of cases. Two patients had a medical history of a stroke and none of the patients had coronaropathy. Sixty-two percent of our patients were overweight and only one patient was obese with a mean body mass index equal to 25,6 ± 3,6 Kg/m². The mean blood pressure was 140/80 mmHg. The mean heart rate was 82 ± 19 bpm. The electrocardiogram was pathological in 25% of the cases, revealing shortening in the QT interval. All patients had echocardiography. It was pathological in six patients having shown hypertensive cardiopathy in four patients, left ventricular hypertrophy in five patients associated with mitral insufficiency in one patient, and an ischemic heart failure in one patient.

Conclusion: Based on the current evidence, cardiovascular disease is not included among the criteria needed for parathyroidectomy. Thus, long-term longitudinal randomized trials are needed to determine the impact of surgery on cardiovascular diseases and mortality in PHPT.