ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Association between androgen levels and SPISE index in patients with polycystic ovarian syndrome
Lena Radic 1 , Sanja Ognjanovic 1 , Bojana Popovic 1 , Dusan Ilic 1 , Jelica Bjekic Macut 2 , Milica Opalic 1 , Valentina Elezovic Kovacevic 1 , Olivera Stanojlovic 3 , Dragan Hrncic 3 , Danijela Vojnovic Milutinovic 4 & Djuro P. Macut 1
1Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Centre of Serbia, Department for Endocrine Tumors and Hereditary Cancer Syndromes, Belgrade, Serbia; 2Clinical Hospital Centre Bezanijska Kosa, Belgrade, Serbia; 3Institute of Physiology, Faculty of Medicine, Belgrade, Serbia; 4IBISS, University of Belgrade, Belgrade, Serbia
Introduction: Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic oligo-/anovulation and polycystic ovarian morphology. Hyperandrogenism is a key diagnostic feature of PCOS and according to ESHRE/ASRM criteria it can be clinical and/or biochemical. SPISE index (single-point insulin sensitivity estimator index) is a new indicator of insulin sensitivity and a predictor of abnormal glucose metabolism. The aim of the research was to analyse association between SPISE index and androgenic disorders which are highly prevalent in PCOS.
Subjects and methods: We analysed 145 female patients with PCOS diagnosed using ESHRE/ASRM criteria and with exclusion of relevant diseases. Patients were divided according to age into two groups, ≤ 30 years (PCOS A, n: 74, age: 23.3±3.1 years, body mass index (BMI): 23.1±4.4 kg/m2) and >30 years old (PCOS B, n: 71, age: 35.6±4.9 years, BMI: 25.3±6.3 kg/m2). We measured serum levels of total cholesterol, LDL and HDL cholesterol, triglycerides, total testosterone, SHBG, DHEA-S, androstenedione and 17OH-progesterone, while values of free androgen index (FAI) and SPISE index were calculated using appropriate formulas. Statistical analysis was performed using the SPSS software.
Results: The two groups did not differ in BMI (23.3±4.4 vs. 25.3±6.3 kg/m2, P=0.126), waist circumference (77.0±12.9 vs. 82.0±15.2 cm, P=0.071) and total testosterone levels (2.0±1.0 vs. 1.9±0.9 nmol/l, P=0.332). SPISE index was lower in PCOS B group (PCOS A:PCOS B: 8.7±2.6 vs.7.6±2.6, P=0.022). There was a statistically significant higher value of SHBG in B group (PCOS A:PCOS B: 44.0±30.7 vs. 48.2±17.1 nmol/l, P=0.037), but there was no difference in FAI (P=0.291). The SPISE index positively correlated with SHBG levels in both groups of patients (PCOS A: P=0.006, PCOS B: P=0.001), but negatively correlated with FAI in B group (P=0.018).
Conclusion: Hyperandrogenism in patients with PCOS is associated with poor metabolic outcome. Our analysis showed worsening of the SPISE index with age of our subjects, and its association with indicators of hyperandrogenism could predict metabolic events during the life of patients with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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