ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Maternal cortisol levels in 3rd trimester and early language development, a study of 1,093 mother-child pairs from Odense Child Cohort
Hanne Mumm 1 , Anja Fenger Dreyer 1,2 , Dorthe Bleses 3 , Dorte Glintborg 1,2 , Tina Kold Jensen 4,5,6 , Henriette Boye 4,6 , Fabio Trecca 3 & Marianne Andersen 1,2
1Odense University Hospital, Department of Endocrinology, Odense, Denmark; 2University of Southern Denmark, Department of Clinical Research, Faculty of Health Sciences, Odense, Denmark; 3Aarhus University, TrygFonden’s Centre for Child Research and School of Communication and Culture, Aarhus V, Denmark; 4Odense University Hospital, Odense Child Cohort, Hans Christian Andersen Hospital for Children, Odense C, Denmark; 5University of Southern Denmark, Department of Clinical Pharmacology, Pharmacy and Environmental Medicine, Odense, Denmark; 6University of Southern Denmark, OPEN Patient data Explorative Network (OPEN), Odense, Denmark
Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in the association.
Design: Prospective observational study.
Setting: Odense Child Cohort.
Patients: The study cohort included 1,093 mother-child dyads (570 boys and 523 girls).
Intervention: Fasting morning serum (s-) cortisol was collected from 3rd trimester (gestational week 26-28) pregnant women and measured by liquid chromatography–tandem mass spectrometry.
Main Outcome Measures: Offspring receptive and productive vocabulary assessments by MacArthur-Bates Communicative Development Inventories parent reports were completed every third month from child age 12 to 37 months.
Results: Levels of cortisol were higher in women carrying a girl (858 ± 214 nmol/l) than in women carrying a boy (820 ± 222 nmol/l). Higher 3rd trimester maternal cortisol levels showed a positive association with development of productive vocabulary in boys at age 12-21 months (OR = 1.23, SE = 0.07, P = .005) and age 22-37 months (OR = 1.09, SE = 0.06, P = .967). Higher maternal cortisol levels in 3rd trimester were positively associated with receptive vocabulary in girls at 12-21 months-of-age (OR = 1.16, SE = 0.05, P = .002).
Conclusions: Maternal 3rd trimester s-cortisol levels were positively associated with early language development in children age 12-37 months.
Funding: Salary of presenting author Anja Fenger Dreyer is funded by the Novo Nordisk Foundation as part of a collaborative grant entitled ‘DOUBLE EDGE – Characterization and mitigation of adverse effects of glucocorticoid treatment’ (NNF20OC0063280).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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