ECE2023 Poster Presentations Pituitary and Neuroendocrinology (123 abstracts)
Factors Affecting Quality of Life in Patients with Acromegaly: Single Center Experience
Ayşe Merve Ok 1,2 , Fatih Bektaş 1 , Gamze Bilik Oyman 1 , Ümmü Mutlu 1,3 , Hülya Hacişahinoğulları 1 , Gulsah Yenidunya Yalin 1 , Nurdan Gül 1 , Ayse Kubat Uzum 1 , Ferihan Aral 1 , Sema Yarman 1 & Özlem Soyluk Selçukbiricik 1
1Faculty of Medicine, Istanbul University, Endocrinology and Metabolism, İstanbul, Turkey; 2Şırnak State Hospital, Endocrinology and Metabolism, Şırnak, Turkey; 3Van Training and Research Hospital, Endocrinology and Metabolism, Van, Turkey
Objective: Despite treatment, the quality of life in patients with acromegaly remains lower than in the healthy population due to the classical findings and complications related to the disease. Therefore, in the follow-up of acromegaly, evaluation of quality of life along with symptoms and biochemical parameters is recommended. The aim of our study was to evaluate the quality of life, anxiety and depression status of our acromegaly patients and to assess the factors affecting these.
Material and Methods: Ninety acromegaly patients (46 females, 44 males) followed in our center were included in the study. After completing the demographic information form, four questionnaires were applied to the patients; General Quality of Life Questionnare (EQ-5D-3L), Acromegaly Quality of Life Questionnare (AcroQoL), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Information about disease status, current complications, treatment were obtained from patient records.
Results: The mean age of the study group was 48 11.02 years. The median scores of AcroQoL, BDI, BAI, EQ-5D and EQ-5D/VAS were 76.7 % (61.93-85.5), 10.5 (4.75-15.25), 9 (4-18), 0.779 (0.69-1) and 80 (70-90) respectively. Female patients had higher BAI, BDI scores (P<0.001, P=0.003 respectively) and lower EQ-5D and AcroQoL scores (P=0.004, 0.002 respectively). Patients with elementary school/no education had lower AcroQoL, EQ-5D, EQ-5D/VAS scores and higher BDI score than high school/university graduates (P=0.002, 0.027, 0.037, 0.006 respevtively). There was no significant difference between patients who received replacement therapy for hypopituitarism and those who did not, but the AcroQol and EQ-5D, EQ-5D/VAS score was significantly better and BAI score was worse in those who received gonad replacement therapy (P=0.019, 0.015, 0.02, 0.013 respectively). In addition, patients with diabetes insipidus had higher BDI scores and lower EQ5D scores (P=0.025, 0.05 respectively). There was a negative correlation between follow-up time and AcroQol scores (r=-0.209, P=0.048). Educational status negatively correlated with BDI and BAI scores (r=-0.284, P=0.007; r=-0.267, P=0.011), and were positively correlated with EQ-5D, EQ-5D/VAS and AcroQol scores (r=0.291, P=0.005; r=0.287, P=0.006; r=0.361, P<0.001).
Conclusions: Gender and educational status are the main determinants of quality of life, depression and anxiety in acromegaly patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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