ECE2023 Poster Presentations Calcium and Bone (83 abstracts)
Influence of musculoskeletal status on fracture risk in patients with adult hypophosphatasia
María Del Carmen Andreo-Lopez 1 , Victoria Contreras Bolivar 1,2 , Enrique Moratalla-Aranda 2,3 , Trinidad González-Cejudo 2,4 , Luis Martínez-Heredia 2 , Francisco Andújar-Vera 2,5,6,7 , Cristina García-Fontana 1,2,5 , Beatriz García-Fontana 1,2,5 & Manuel Muñoz-Torres 1,2,5,8
1Endocrinology and Nutrition Unit, San Cecilio Clinical University Hospital, Granada, Spain; 2Institute of Biosanitary Research of Granada (ibs.GRANADA), Granada, Spain; 3Nuclear Medicine Unit, San Cecilio Clinical University Hospital, Granada, Spain; 4Clinical Analysis Unit, San Cecilio Clinical University Hospital, Granada, Spain; 5CIBER on Frailty and Healthy Aging (CIBERFES), Carlos III Health Institute, Granada, Spain; 6Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain; 7Andalusian Institute for Research in Data Science and Computational Intelligence, (Instituto DaSCI), Granada, Spain; 8Department of Medicine, University of Granada, Granada, Spain
Introduction: Hypophosphatasia (HPP) is an inherited disease, characterized by a non-tissue-specific alkaline phosphatase deficiency that leads to abnormal mineralization of bone tissue, which promotes fragility fractures. A defective muscle status could have important clinical repercussions on fracture risk. The aim of this work was to evaluate the relationship between bone and muscle compartment.
Material and Methods: Observational cross-sectional study in adults with PPH. Demographic (age, sex), analytical (alkaline phosphatase (ALP), normal range: 30-120 U/l), and clinical variables (fractures, kilograms (kg) of muscle strength with Jamar dynamometer -cut-off point: <p10 of Spanish population-, rectus femoris quadriceps muscle mass with ultrasound -Sonosite S-Nerve®- and bone mineral density with dual energy X-ray absorptiometry expressed according to T and Z-score. Statistical analysis was performed with IBM SPSS v.25.
Results: Twenty-one subjects were studied. 54% women, mean age: 49±18 years. The mean FA was 28±12U/l. 41% presented at least 1 bone fracture. Mean dynamometry was 28±11kg, 100% with good muscle strength. In the nutritional morphological assessment, the mean Y-axis measurement was 1.5±0.7 and muscle area, 4.8±2.5. The mean T-score in lumbar spine (L1-L4) was -0.8±1.5 and in femoral neck (FC) -1.3±0.9. The mean Z-score in L1-L4 was 0.08±1 and in CF 0.06±1.1. Muscle strength was positively correlated with Y-axis (r=0.52, P=0.02), with muscle area (r=0.51, P=0.02), with T and Z-score in CF (r=0.64, P=0.002) and with T and Z-score in L1-L4 (r=0.51, P=0.02).
Conclusions: There is a high prevalence of fractures in patients with PPH. A positive correlation was observed between the muscle and bone compartments. Therefore, enhancing the muscle compartment in PPH patients could reduce the risk of fracture in these patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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