ECE2023 Poster Presentations Calcium and Bone (83 abstracts)
Evaluation of Laboratory Findings of Primary Hyperparathyroidism in Geriatric Patients
Murat Calapkulu 1 , Muhammed Erkam Sencar 2 , Davut Sakiz 3 , Merve Tekinyildiz 4 , İlknur Ozturk Unsal 5 & Erman Cakal 5
1Igdır State Hospital, Endocrinology and Metabolism, Igdır, Turkey; 2Medicana International Hospital, Endocrinology and Metabolism, Ankara, Turkey; 3Mardin Training and Research Hospital, Endocrinology and Metabolism, Mardin, Turkey; 4University of Health Sciences Dıskapı Yıldırım Beyazıt Training and Research Hospital, Internal Medicine, Ankara, Turkey; 5University of Health Sciences Dıskapı Yıldırım Beyazıt Training and Research Hospital, Endocrinology and Metabolism, Ankara, Turkey
Evaluation of Laboratory Findings of Primary Hyperparathyroidism in Geriatric Patients
Background: Primary hyperparathyroidism (PHPT) is an endocrine disease characterized by excessive secretion of parathormone (PTH) from one or more parathyroid glands. In recent studies, it has been reported that the PHPT clinic has turned into a largely asymptomatic disease in recent years. There are few studies on the effect of aging on laboratory findings of PHPT. We aimed to evaluate the laboratory findings of PHPT in the geriatric patient population and to determine the differences by comparing them with general PHPT patients in the current study.
Methods: A total of 182 patients operated on with the diagnosis of PHPT in our center between 2017-2019 were included in the current study. The patients’ demographic, laboratory, and pathological data were recorded by scanning the files. Patients were divided into two groups as <65 years old and ≥65 years old.
Results: The patients comprised 149 females and 33 males with a mean age of 55.1±12.3 years. The full demographic and clinical data of the PHPT patients are reported in Table 1. No differences were found in serum PTH, calcium, phosphorus, alkaline phosphatase, creatinine, or 25-OH-D levels between the two groups. Urinary calcium levels were found to be significantly lower in geriatric patients. There was a significant negative correlation between urinary calcium level and age. The frequency of kidney stones was found to be less frequent in the geriatric patient group (12.9%& 32.1%, p:0.01). When postoperative transient hypocalcemia was evaluated, no significant difference was found between the two groups.
| Parameter | ≥65 years (n:46) | <65 years (n:136) | P-value |
| Age (years) | 70.9±4.9 | 49.7±9.1 | <0.001 |
| Gender (F/M) | 40/6 | 109/27 | 0.30 |
| Serum parathormone (pg/ml) | 134.1 (76-764) | 136 (71-922) | 0.89 |
| Serum calcium (mg/dl) | 11.2±0.9 | 11.2±0.8 | 0.87 |
| Serum phosphorus (mg/dl) | 2.6±0.6 | 2.7±0.5 | 0.18 |
| Urine calcium excretion (mg/day) | 262 (101-646) | 350.5 (108-1033) | 0.002 |
| Serum ALP (U/l) | 103 (47-260) | 109.5 (53-773) | 0.30 |
| Serum creatinine (mg/dl) | 0.83±0.19 | 0.83±0.2 | 0.99 |
| 25-OH-D (ng/ml) | 20.5±11.1 | 17.3±10.5 | 0.08 |
| Adenoma weight (gr) | 0.7 (0.12-5) | 0.91 (0.1-10) | 0.26 |
Conclusion: Clinical and laboratory findings of PHPT are affected by aging. Recent studies have shown that the disease is more often asymptomatic in the geriatric population than in young people and is characterized by a predominance of bone involvement. Clinical and laboratory findings of PHPT in geriatric patients may be better elucidated in multicenter studies involving larger patient populations.
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more