ECE2023 Poster Presentations Reproductive and Developmental Endocrinology (108 abstracts)
Predictive factors of infertility among patients with polycystic ovary syndrome
Mouna Elleuch , Hamdi Frikha , Molka Triki , Dhoha Ben Salah , Trigui Souleima , Nadia Charfi , Mouna Mnif , Fatma Mnif , Nabila Rekik Majdoub , Faten Haj Kacem Akid & Mohamed Abid
Hedi Chaker University Hospital, Department of Endocrinology
Introduction: Polycystic ovary syndrome (PCOS) is occurring in approximately one in seven women. Infertility is a major issue in PCOS. Recognizing patients with higher risk of infertility is still a matter of debate.
Aim: Study the predictive factors of female infertility in patients with PCOS
Methods: A retrospective, single-center, comparative and analytical study including patients with PCOS followed at the endocrinology department of Hedi Chaker University Hospital of Sfax, Tunisia. G1 included PCOS patients with inability to conceive and G2 included fertile PCOS patients.
Results: We compared two groups. Of whom 30 had fertility issues (G1). And 20 fertile patients. Age was comparable between the two groups. Using univariate analysis, G1 patients had higher frequency of menstrual disturbances (87.2% vs 63.6% P=0.04) and obesity rates (66% vs 40.7%; P=0.035). Other comorbidities, PCOS features, metabolic and hormonal parameters did not significantly differ between the two groups. Using multivariate analysis, PCOS phenotypes (P=0.04; OR=1.2 ;CI [1.01-1.4]), menstrual disturbances (P=0.01, OR=2.1, CI[1.2-2.4]) and BMI (P=0.045; OR=1.12; CI[1.1-1.4]) were significantly associated with poor fertility outcomes.
Discussion & Conclusion: PCOS is one of the most common infertility causes due to its strong association with hyperandrogenism and dysovulation. In a large, multicenter study Rausch et al. found that BMI, hirsutism score and duration of attempting conception were the main predictors of fertility outcomes. Rafique et al. were able to construct an infertility risk score for patients with PCOS that featured age, BMI, oligo/anovulation, androgen excess and ovary volume on transvaginal sonography as the major conception failure determinants. In conclusion, every PCOS patient should be assessed and counseled regarding fertility derangements using a personalized approach.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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